| Brainstorm | Updates for Argentina: +72558 cases, +47 deaths since 6 days ago | 00:00 |
|---|---|---|
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): NEJM: remdesivir analog VV16 similar to Paxlovid in Chinese trial. Main issue is there was no placebo, only Paxlovid comparison, so unclear how much the patients benefited vs no treatment. Minor issue: non-blinded patients self-reported symptoms used [... want %more?] → https://twitter.com/michaelzlin/status/1610050583985287168 | 00:18 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Sustained clinical recovery was symptoms dropping to mildest level for 2d.Most were vaccinated. Median 4d from symptom onset to 1st dose. Adding 3d incubation period → 7d from infection. This is similar to the Paxlovid trial, so expect low rebound [... want %more?] → https://twitter.com/michaelzlin/status/1610054349425881088 | 00:27 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): This is related to why I am unconvinced by the claim that changing the mutational spectrum by mutagenizing SARSCoV2 with molnupiravir will be innocuous for viral evolution.Changing the spectrum means making certain combinations of mutations much [... want %more?] → https://twitter.com/michaelzlin/status/1610061547753320449 | 00:56 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): As Bloom points out with XBB.1.5 (forwarding @LongDesertTrain), SARSCoV2 is nowhere close to having sampled all possible beneficial mutationsThis was mathematically obvious but there were some vocal voices dismissing this concern as FDA was [... want %more?] → https://twitter.com/michaelzlin/status/1610064468406603781 | 01:16 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): That's >75% for the XBB.1.5 variant accounting for new cases → https://twitter.com/EricTopol/status/1610074911229509632 | 01:55 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): ~63% of Americans age 65+ have not had a recent/bivalent booster, leaving them vulnerable —Lab data supports some bivalent booster cross-immunity protection vs XBB.1.5, even though it was BA.5 directed—Before XBB.1.5 becomes dominant across the US, that's a [... want %more?] → https://twitter.com/EricTopol/status/1610078887287074816 | 02:04 |
| Brainstorm | Updates for Norway: +248 cases since a day ago | 02:05 |
| ikun | %cases | 03:19 |
| Brainstorm | ikun: the world has had 668.1 million confirmed cases (8.7% of all people) and 6.7 million deaths (1.0% of cases; 1 in 1135 people) as of 2 days ago. 8.8 billion tests were done (1.1 per capita, 7.6% positive). 3.4 billion were vaccinated (44.0%). +126 cases since 3 days ago. See https://offloop.net/covid19/?default=the%20world&legacy=no | 03:19 |
| ikun | %cases USA | 03:21 |
| Brainstorm | ikun: United States has had 102.7 million confirmed cases (31.2% of all people) and 1.1 million deaths (1.1% of cases; 1 in 295 people) as of 14 minutes ago. 1.2 billion tests were done (3.5 per capita, 8.9% positive). 244.9 million were vaccinated (74.3%). +158873 cases, +398 deaths since 22 hours ago. See https://offloop.net/covid19/?default=United%20States&legacy=no | 03:21 |
| ikun | %cases china | 03:21 |
| Brainstorm | ikun: China has had 4.6 million confirmed cases (0.3% of all people) and 17198 deaths (0.4% of cases; 1 in 81517 people) as of 15 hours ago. 2.1 billion tests were done (1.5 per capita, 0.2% positive). +20230 cases, +74 deaths since 23 hours ago. See https://offloop.net/covid19/?default=China&legacy=no | 03:21 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): Below a nice summary of what's known about XBB.1.5 for the moment. twitter.com/jbloom_lab/sta… → https://twitter.com/TWenseleers/status/1610098910625730568 | 03:30 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): A dashboard of variant frequencies over the past 2 weeks in the US by @RajlabN based on the GISAID data can also be found below. Also shows XBB.1.5 made up 36% of all sequenced samples in the US the past 2 weeks. public.tableau.com/app/profile/ra… → https://twitter.com/TWenseleers/status/1610103279756738560 | 03:49 |
| Brainstorm | New from r/Science: science: Two new US studies describe pediatric COVID-19, one finding that 7.0% of hospitalized children developed neurologic complications such as seizures, and the other showing that even mild infections can lead to long COVID → https://old.reddit.com/r/science/comments/101wydl/two_new_us_studies_describe_pediatric_covid19_one/ | 04:57 |
| Brainstorm | New from ##covid-19 Zotero group: COVID-19 and Acute Neurologic Complications in Children: Type Journal Article Author James W. Antoon Author Matt Hall Author Leigh M. Howard Author Alison Herndon Author Katherine L. Freundlich Author Carlos G. Grijalva Author Derek J. Williams Volume 150 Issue 5 Pages e2022058167 [... want %more?] → https://www.zotero.org/groups/covid_links/items/J9663HIU | 05:17 |
| Brainstorm | Updates for Germany: +40783 cases, +249 deaths since 23 hours ago | 06:01 |
| LjL | <Brainstorm> New from r/WorldNews: worldnews: China orders Covid-19 sewage watch as ‘living with virus’ begins → https://www.reddit.com/r/worldnews/comments/101xsrg/china_orders_covid19_sewage_watch_as_living_with/ | 06:23 |
| Brainstorm | Updates for Wisconsin, United States: +2198 cases, +5 deaths since 2 days ago — Colorado, United States: +1444 cases since 2 days ago — Thuringen, Germany: +620 cases, +15 deaths since 2 days ago — Bashkortostan, Russia: +364 cases since a day ago | 07:03 |
| Brainstorm | Updates for Portugal: +3883 cases, +91 deaths since 11 days ago | 08:06 |
| Brainstorm | New from r/COVID19: COVID19: Comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans → https://old.reddit.com/r/COVID19/comments/10210ec/comparative_effectiveness_of_third_doses_of/ | 08:08 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | January 03, 2023: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/10221vh/daily_discussion_thread_january_03_2023/ | 09:06 |
| Brainstorm | Updates for Taiwan: +25005 cases, +22 deaths, +38824 tests since a day ago | 09:08 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: New Covid subvariant XBB.1.5 is ‘wakeup call’ for UK and behind one in 25 cases: Waning immunity, more indoor mixing because of the cold weather and lack of other mitigations, such as wearing facemasks, are [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/1022wvn/new_covid_subvariant_xbb15_is_wakeup_call_for_uk/ | 10:42 |
| Brainstorm | New from r/COVID19: COVID19: Mid- and Long-Term Atrio-Ventricular Functional Changes in Children after Recovery from COVID-19 → https://old.reddit.com/r/COVID19/comments/1023pnl/mid_and_longterm_atrioventricular_functional/ | 10:52 |
| Brainstorm | Updates for Lithuania: +774 cases, +3 deaths since 23 hours ago | 11:00 |
| Brainstorm | New from StatNews: Covid’s winter surge is poised to exceed summer peak: Even if Covid will be little more than a nuisance for many on an individual level, others who may not realize the virus remains a threat to them — particularly… → https://www.statnews.com/2023/01/03/covid-winter-surge-to-exceed-summer-peak/ | 11:11 |
| Brainstorm | New from Politico: Coronavirus: ‘Unacceptable.’ China blasts countries for imposing COVID tests on travelers → https://www.politico.eu/article/covid-tests-on-chinese-travellers-unacceptable-to-beijing-warns-of-counter-measures/ | 11:49 |
| Brainstorm | Updates for Poland: +693 cases, +13 deaths, +8612 tests since 23 hours ago | 12:02 |
| Brainstorm | New from Retraction Watch: Elsevier journal temporarily removes article by prolific psychologist – with a typo at “frist”: An Elsevier psychology journal took down an article in early December with a notice that appeared to be an internal [... want %more?] → https://retractionwatch.com/2023/01/03/elsevier-journal-temporarily-removes-article-by-prolific-psychologist-with-a-typo-at-frist/ | 12:08 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Travellers from China who test positive in UK for Covid will not need to isolate → https://old.reddit.com/r/Coronavirus/comments/1025i9b/travellers_from_china_who_test_positive_in_uk_for/ | 12:56 |
| Brainstorm | New from ScienceNews: Brain scans suggest the pandemic prematurely aged teens’ brains: A small study suggests that the COVID-19 pandemic may have aged teen brains beyond their years. → https://www.sciencenews.org/article/covid-pandemic-prematurely-aged-teens-brains | 13:06 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 03JAN22 → https://old.reddit.com/r/nCoV/comments/1026hud/global_covid_cases_for_03jan22/ | 13:16 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): Good primer on new XBB.1.5 variant from Jesse Bloom —“whether increase in fraction of cases due to XBB.1.5 will lead to surge in absolute number of cases is still not certain” twitter.com/jbloom_lab/sta… → https://twitter.com/ScottGottliebMD/status/1610252915805130753 | 13:35 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Coronavirus strain causes 'double-whammy' of concern: we look at the doubling time in the prevalence to see how fast a variant is spreading and this one went from 20% last week to about 40% this week in the U.S." → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/10271tr/coronavirus_strain_causes_doublewhammy_of_concern/ | 13:45 |
| Brainstorm | Updates for Philippines: +135052 cases, +20 deaths since a day ago — Malta: +53 cases since 21 hours ago — Bangladesh: +31 cases since 21 hours ago | 14:07 |
| de-facto | %title https://www.nature.com/articles/s41467-022-35638-y | 14:41 |
| Brainstorm | de-facto: From www.nature.com: Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 | Nature Communications | 14:41 |
| Brainstorm | Updates for Iran: +119 cases, +3 deaths since 23 hours ago | 15:09 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): A 'Cold War' of COVID variants? - China with little data on its epidemic & variants.- U.S.A. with the new variant XBB.1.5 that is spreading fast.U.S.A. wants to restrict Chinese travel & what happens to U.S.A. if XBB.1.5 is as transmissible as some of their [... want %more?] → https://twitter.com/Tuliodna/status/1610275493475160067 | 15:13 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): In summary, it is not first time that recombinants emerge with Spike F486P. Will Omicron XBB.1.5 with Spike F486P mutation increase cases, hospitalisation and deaths in USA & the globe? Or will follow the fate of XAY in SA and disappear? → https://twitter.com/Tuliodna/status/1610288906129313793 | 16:02 |
| Brainstorm | New from StatNews: Beijing rebukes new Covid testing requirements for travelers from China: Australia, Canada, and the U.S. are among countries now requiring travelers from China to take a COVID-19 test prior to boarding their flight. → https://www.statnews.com/2023/01/03/china-covid-testing/ | 16:41 |
| Brainstorm | Updates for Bosnia and Herz.: +35 cases, +2 deaths since 23 hours ago | 17:01 |
| LjL | Tuvix: I was told about the changed recommendation for aspirin in the other channel. I really don't know how relevant it is if you're only taking it while you actively have COVID, when you'd be taking psracetsmol or an NSAID for a few days anyway, but de-facto for instance kept taking it for a time afterwards and also after getting the vaccine (the "cardiac" dosage). One could call that overkill ;P but I guess it means at minimum I should really dig up studies about | 17:04 |
| LjL | it actually helping in or after the acute phase before contemplating replacing paracetamol or whatnot with it. Because really most of my mental imagery is around Italian hospital directors that were interviewed on TV and said their small studies showed benefit with aspirin and that they didn't understand why it wasn't being done widely | 17:04 |
| LjL | Aspirin or numesulide, specifically. But the latter is even more problematic in general I guess. | 17:05 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Today we're worried by XBB.1.5 which reached 40% of US cases. David Ho's paper called its immunoevasiveness "alarming"XBB.1.5 is a BA.2 derivative. I had said as early as June that FDA should request a BA.2+BA.5 booster. Instead FDA went [... want %more?] → https://twitter.com/michaelzlin/status/1610316457480695810 | 17:49 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Anyway some background info for you to trace the logic. First information on XBB.1 origins from BA.2twitter.com/jbloom_lab/sta… → https://twitter.com/michaelzlin/status/1610318091942084613 | 17:58 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Article at @cnn quoting Trevor Bedford @trvrb that we can expect another rising surge fueled by XBB.1.5 immunoevasivenesscnn.com/2023/01/03/hea… → https://twitter.com/michaelzlin/status/1610320734932406273 | 18:08 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): But we'd be better protected now, with fewer breakthrough cases and hospitalizations among the booster, if that booster had been BA.2+BA.5. Again with multiple derivatives of BA.2. and BA.5 going around in July when FDA chose BA.5, it was clear that [... want %more?] → https://twitter.com/michaelzlin/status/1610323997291315201 | 18:18 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): And finally XB.1.5 is a mutant that those loudly pronouncing the end of SARSCoV2's evolutionary abilities in 2021 (plays well to the press) would have called an "edge case" or "theoretical concern only"We need to learn not to dismiss such [... want %more?] → https://twitter.com/michaelzlin/status/1610324842364174337 | 18:28 |
| Brainstorm | New from BBC Health: We're focussed on supporting NHS - health secretary: Steve Barclay blames pandemic for health service woes, but insists government has right plan in place. → https://www.bbc.co.uk/news/health-64151557 | 18:47 |
| Brainstorm | New from Politico: EU countries near deal on bloc-wide response to China’s COVID surge: National capitals 'converged' on several measures for travelers but will continue talks on Wednesday. → https://www.politico.eu/article/european-countries-covid-china-bloc-wide-response-measures-travelers/ | 19:07 |
| Brainstorm | New from r/COVID19: COVID19: Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution → https://old.reddit.com/r/COVID19/comments/102g5fi/mutation_rate_of_sarscov2_and_emergence_of/ | 20:06 |
| Brainstorm | Updates for South Korea: +78575 cases, +54 deaths since a day ago — Canada: +165 cases since 20 hours ago | 20:08 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): @TWenseleers @C_Althaus Not sure if that is a fair comparison? SARS-CoV-2 is still adapting to us and, prior to much immunity and with still pockets of little immunity, it still gets a lot of space. It will run out of major changes, and start cycling at some point. → https://twitter.com/Marc_Veld/status/1610352408294576128 | 20:15 |
| LjL | de-facto, a good time to start monitoring South Korea i suspect | 20:24 |
| de-facto | why South Korea? | 20:25 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): China estimates 250mn people have caught Covid in 20 days ft.com/content/1fb604… → https://twitter.com/TWenseleers/status/1610355823489712141 | 20:25 |
| LjL | de-facto, cases increasing, although R is still very close to 1 | 20:25 |
| LjL | i think it will increase. just a hunch. | 20:25 |
| LjL | <CarlSagan> [Ars Technica - Science] New omicron subvariant surges to 40.5% as COVID hospitalizations rise https://arstechnica.com/?p=1907203 2023-01-03T17:18:06 | 20:26 |
| de-facto | possible, but it also may already have peaked, https://i.imgur.com/x3vR1fs.jpeg | 20:28 |
| LjL | de-facto, i asked before, but my memory is what it is, do you commonly use any other variant graphs per country than outbreak.info? i seem to remember you showing a different-looking graph from https://outbreak.info/location-reports?loc=KOR&xmin=2022-07-03&xmax=2023-01-03 for example | 20:30 |
| LjL | (although maybe it's the same data anyway) | 20:30 |
| de-facto | in South Korea the peak possibly may have been due to BA.2.75 and BQ.1 according to https://covariants.org/per-country | 20:31 |
| de-facto | btw what makes you think we will see a peak in South Korea specifically? | 20:34 |
| Brainstorm | New from ##covid-19 Zotero group: Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster: Type Journal Article Author Meredith E. Davis-Gardner Author Lilin Lai Author Bushra Wali Author Hady Samaha Author Daniel Solis Author Matthew Lee Author Andrea Porter-Morrison Author Ian T. Hentenaar [... want %more?] → https://www.zotero.org/groups/covid_links/items/8UZQF99X | 20:34 |
| LjL | %w hunch | 20:42 |
| Brainstorm | LjL, hunch — noun: 1. A hump; a protuberance, 2. A stooped or curled posture; a slouch, 3. A theory, idea, or guess; an intuitive impression that something will happen, 4. A hunk; a lump; a thick piece, 5. A push or thrust, as with the elbow [... want %more?] → https://en.wiktionary.org/wiki/hunch | 20:42 |
| LjL | 3 | 20:42 |
| LjL | <Brainstorm> New from Politico: EU countries near deal on bloc-wide response to China’s COVID surge: National capitals 'converged' on several measures for travelers but will continue talks on Wednesday. → https://www.politico.eu/article/european-countries-covid-china-bloc-wide-response-measures-travelers/ | 20:44 |
| de-facto | but lets increase airtraffic with untested passengers from USA, they got the best variants so far! | 20:47 |
| de-facto | maybe we could subsidize parties for them to really seed infection chains simultaneously | 20:47 |
| de-facto | XBB.1.5 got the ability to circumvent the most prevalent immunity in both USA and EU | 20:51 |
| de-facto | LjL have you seen the paper i linked above? | 20:55 |
| de-facto | %print https://twitter.com/mrmickme/status/1608334841338269696 | 20:55 |
| Brainstorm | de-facto, It says: Michael on Twitter: "This could be the single most important paper to come out since the start of the pandemic. Long-term rewiring of innate immunity. Learned down reg of Neutrophils and Monocytes leading to enhanced 2ndry infections, leading to huge of sepsis from these. https://t.co/WO9dO1Ms5v" / Twitter | 20:55 |
| de-facto | %print https://twitter.com/fitterhappierAJ/status/1608886846892957697 | 20:56 |
| Brainstorm | de-facto, It says: Anthony J Leonardi, PhD, MS on Twitter: "It looks like Covid suppresses innate immunity toward other viruses and Bacteria This doesn't bode well for the severity of other infections that aren't even covid Think of all the people saying "The worst cold of my life" Mild covid is harming the response to the common cold https://t.co/aKEoH5dpHo" / Twitter | 20:56 |
| de-facto | %title https://www.nature.com/articles/s41467-022-35638-y | 20:57 |
| Brainstorm | de-facto: From www.nature.com: Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 | Nature Communications | 20:57 |
| LjL-Matrix | de-facto: I haven't seen it but I've heard people perhaps in the other channel making this claim, so probably based on this paper. I'm not sure I'm in the right mood to get super scared again, and most of the people I know that I could rationally discuss this with... currently have COVID | 20:58 |
| LjL | but i'll default to it being important and zotero it | 20:59 |
| de-facto | i thought it may be of interest to you as you previously had linked sources claiming that with each infection COVID may become worse | 21:02 |
| de-facto | so IF that was the case, this paper probably would be relevant for that | 21:02 |
| LjL | :( | 21:02 |
| LjL | I definitely remember that one | 21:02 |
| LjL | I'm honestly at the limit of what I can take without starting to scream | 21:03 |
| Brainstorm | New from ##covid-19 Zotero group: Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19: Type Journal Article Author Allison K. Maher Author Katie L. Burnham Author Emma M. Jones Author Michelle M. H. Tan Author Rocel C. Saputil Author Laury Baillon Author [... want %more?] → https://www.zotero.org/groups/covid_links/items/JE3PA59U | 21:03 |
| LjL | sometimes past that limit | 21:03 |
| LjL | de-facto, this is the one i had previously linked https://www.nature.com/articles/s41591-022-02051-3 | 21:04 |
| de-facto | I am not convinced of a too pessimistic view (as from the impact COVID has on our daily live decreased) yet it definitely is required to have an open mind, especially for any potential longterm effect on the immune system | 21:04 |
| LjL | "Re-infection" tag on Zotero has a limited number of papers in it | 21:04 |
| de-facto | %title | 21:05 |
| Brainstorm | de-facto: From www.nature.com: Acute and postacute sequelae associated with SARS-CoV-2 reinfection | Nature Medicine | 21:05 |
| de-facto | ah yeah that one, i remember we were discussing if there could have been a selection bias for cofounding factors, or if they even would have been able to exclude that | 21:06 |
| LjL | i must admit the abstract of your paper is barely understandable to me | 21:06 |
| de-facto | immunity always is very complex, but researching the longterm effects from COVID on the immune system is required for understanding long lasting symptoms aka long COVID etc | 21:11 |
| de-facto | not only the increased thrombotic risk but also re-programming of the immune system responses may be an issue, for example in fighting off other pathogens | 21:12 |
| Brainstorm | New from r/COVID19: COVID19: Molecular surveillance of potential SARS-CoV-2 reservoir hosts in wildlife rehabilitation centers → https://old.reddit.com/r/COVID19/comments/102iavp/molecular_surveillance_of_potential_sarscov2/ | 21:32 |
| LjL | de-facto, yes and that idea is very scary to me | 21:33 |
| LjL | i don't understand it from the study, i just understand what you say and what the tweets say | 21:33 |
| LjL | and also what's scary is the fact that currently everyone i know seems to be getting COVID | 21:33 |
| LjL | while officially there's not even a peak | 21:34 |
| LjL | but there obviously is | 21:34 |
| LjL | I don't have it in me to bear more than three years of this shit. I laughed bitterly when Trump said "we'll all be together by Easter" in 2020, but, now it's 2023, and I did (like most people, I guess) originally think *at some point* it would be "over". now 1) it won't 2) i keep learning that it's worse than i thought | 21:35 |
| LjL | it's too much, i'll die of fear before i die of covid | 21:35 |
| LjL | you've had covid, how can you not feel fear when you read that it may imply that your defenses against *any* future illness will be impaired, maybe forever? | 21:35 |
| LjL | or, maybe you do feel fear, and you just take it and cope, i guess | 21:36 |
| de-facto | i have had 3 vaccines and COVID (probably BA.5) for a week and I feel fine, i even had a cold during December (not covid but whatever was circulating in Germany, everybody i know got it) yet it was barely noticeable for me, others had to fight with it for two weeks | 21:40 |
| de-facto | yet i think we should keep an open mind to possible longterm effects by COVID, especially on the immune system, its important as potentially so many could be affected by it in one way or the other, but that does not mean we should be too pessimistic, the sooner we understand the details of the mechanisms involved the better our chances of controlling such effects | 21:42 |
| Brainstorm | New from Reddit (test): nCoV: New COVID variant 'could be the one to watch out for in 2023' after surge in cases, expert warns | 03JAN22 → https://old.reddit.com/r/nCoV/comments/102ipnb/new_covid_variant_could_be_the_one_to_watch_out/ | 21:42 |
| de-facto | I think taking it serous in terms of ensuring a healthy lifestyle could be one positive effect from it | 21:43 |
| Brainstorm | New from Reddit (test): nCoV: Examination of COVID-19 vaccine reactions after multisystem inflammatory syndrome in children | Link to peer reviewed study in comments | 03JAN22 → https://old.reddit.com/r/nCoV/comments/102izpe/examination_of_covid19_vaccine_reactions_after/ | 21:52 |
| LjL | de-facto, pwr22: anyway since I don't really understand the paper, can you help me pick the most relevant tags for it on Zotero? Typically I only put there papers where I at least understand the abstarct. So I only added tag "Immunity" (it also came with tags of its own, but those are not standard tags I use in the Zotero). https://www.zotero.org/groups/4391070/covid_links/collections/4HEWBIA7/items/JE3PA59U/item-details you can see the tags I do use in the bottom | 21:57 |
| LjL | left | 21:57 |
| LjL | does "Long COVID" apply? Probably not, because these samples were taken during the acute phase, so we have no idea? | 21:57 |
| LjL | "Consequences"? That's generic but I've used it sometimes | 21:57 |
| LjL | "Thrombosis"? I haven't really looked at that part of the paper at all | 21:58 |
| LjL | "Antibodies"? but this isn't about the anti-COVID antibodies that tag is usually for | 21:59 |
| LjL | I'm going to have dinner, let me know if you think some should apply | 21:59 |
| LjL | I might want to eat some sand and cover myself in it, bbl | 21:59 |
| Brainstorm | Updates for Dominican Rep.: +3323 cases since 18 days ago — Ukraine: +3203 cases, +47 deaths since 8 hours ago — Luxembourg: +1404 cases, +11 deaths since 11 days ago — Uzbekistan: +549 cases since 11 days ago | 22:00 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Without additional knowledge, it seems the greater binding to ACE2 gives XBB.1.5 the advantage. But, it is a Omicron lineage (cross of 2) and major change in disease severity is not expected: immunity will hold in those with vaccines and good immune responses. → https://twitter.com/Marc_Veld/status/1610381706925596672 | 22:12 |
| de-facto | yeah id say long covid, thrombosis at least | 22:13 |
| de-facto | in addition to the tags zotero already pulled from nature | 22:13 |
| de-facto | (heh thats pretty cool) | 22:13 |
| pwr22 | From my skimming it's largely focussed on changes to monocyte function and thrombophilia as a result | 22:15 |
| pwr22 | Haven't really seen anything long-covidey myself yet | 22:15 |
| pwr22 | I'm not really capable of understanding this in detail though | 22:15 |
| Tuvix | Is that the one on down-regulation of (general, including non-COVID) innate immunity? Maybe some tags like 'regulate' or 'immunity' would apply too. Fair warning though, I've only skimmed the paper and it gets a bit involved from what I've seen so far. | 22:15 |
| pwr22 | As I understand it, rather than being in the "innate immune" or "look for pathogens / unexpected things" mode they move to the mode they would be triggered into when clotting behaviour is desired, i.e. the behaviour they would be in if bleeding is detected | 22:15 |
| pwr22 | At least that's so far what this seems to be discussing to me | 22:16 |
| Tuvix | There was a section about introducing common-cold viruses and the change in behavior too; maybe that was specific to the lack of targeting the cold cell and instead being too busy in the clotting mode? | 22:17 |
| pwr22 | Yeah I think that's what it's getting at there | 22:17 |
| Tuvix | I didn't fully understand some of what they were testing there, and without 30+ minutes to read it more carefully I'm sure I've missed some details. | 22:17 |
| pwr22 | I.e. the change in behaviour is not localised to just sensing sars-cov-2 | 22:17 |
| pwr22 | They do at the end admit they should test whether this is novel to covid or whether comparable infections lead to this behaviour | 22:18 |
| Tuvix | Right, it seems to suggest that you're more likely to get pretty much anything your general immune system typically watches out for during & after SARS-CoV-2 infection. | 22:18 |
| pwr22 | I.e. it could be "normal" | 22:18 |
| pwr22 | Also the "covid monocytes" are monocytes taken from blood of active covid sufferers in moderate/severe infection, and healthy is taken from "healthy individuals" (not sure if they are screening for prior covid infections /vaccination) | 22:19 |
| pwr22 | I do know that it's "normal" for inflammatory response / infection to increase clotting risk in general | 22:19 |
| pwr22 | Maybe this is a potential mechanism behind that | 22:20 |
| pwr22 | Wonder if covid is worse than say, a novel flu infection? Or if it's just that it was novel for way more people and that's why we noticed more clotting related things | 22:20 |
| pwr22 | There's some good further studies to do around this area I think - might actually lead to therapeutics that help mediate risk of clots? | 22:21 |
| Tuvix | Sure; I guess the open question is 1) how much worse is COVID infection compared to a baseline 'general infection', and 2) what, if any, lasting effects past the acute-infection phase remain? | 22:21 |
| pwr22 | That behave less coarsely than standard blood thinners, which are risky, particularly after surgery / injury | 22:21 |
| pwr22 | Which is when the risk of clotting is pretty high | 22:21 |
| pwr22 | Woops, when I said "moderate / severe", it should have been "mild / moderate" | 22:25 |
| de-facto | well thats important, because that would mean majorities (thankfully its unlucky minorities for which its severe) | 22:27 |
| pwr22 | Global alterations in innate immune cell phenotypes have been identified in severe COVID-1911,20,21,22. As the main human monocyte population, we focused on deeply characterizing the ex vivo phenotype of classical CD14+ monocytes in uninfected healthy individuals and patients with COVID-19 presenting with mild or moderate symptoms (1-2 or 3-4 WHO ordinal scale for COVID-19 severity, respectively) during the acute phase of disease (Dataset 1). | 22:28 |
| pwr22 | Indeed that is the intent, and to look at newer areas | 22:28 |
| de-facto | we already know that COVID causes inflammatory, thrombotic as well as immune-reprogramming issues, hence having more details about the mechanisms behind that is quite interesting | 22:28 |
| de-facto | i think this is exactly the type of research we need, as it may be relevant for majorities | 22:38 |
| LjL | I have "Immunity" already; I'll go with "Thrombosis" and "Consequences" since you don't quite agree on whether "Long COVID" would be warranted | 22:46 |
| LjL | and here is how I try to remain sane, file these things into files where they're filed and... I don't know | 22:46 |
| LjL | pwr22, this Michael person seems way over the top in general but I just caught this | 22:52 |
| LjL | %print https://twitter.com/mrmickme/status/1609287077669265408 | 22:52 |
| Brainstorm | LjL, It says: Michael on Twitter: "@vijayiyer312 Children would be the first to experience this outcome, given their strong innate immunity and repeat infections in school settings. A perfect recipe for innate immune paralysis." / Twitter | 22:52 |
| LjL | Baseless conjecture, but it does seem like children are being subjected to a whole plethora of infections this year | 22:52 |
| de-facto | %title https://twitter.com/RolandBakerIII/status/1607763227987050497 | 22:52 |
| Brainstorm | de-facto: From twitter.com: Roland Baker on Twitter: "Nature: Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 https://t.co/nj6VidfB8N" / Twitter | 22:52 |
| LjL | We easily attribute it to relaxing of restrictions, etc, but... maybe it *could* have something to do with this? | 22:53 |
| Tuvix | It well may, but the question is still 'how much due to <X> vs. <A> to <W>?' | 22:53 |
| de-facto | a potential big usse may be | 22:54 |
| de-facto | "their gene expression signature and function switched from canonical innate immune functions to a pro-thrombotic phenotype characterized by increased expression of pathways involved in immunothrombosis and increased capacity to form cell aggregates with platelets" | 22:54 |
| Tuvix | A component of RSV is very likely that at least partial remote-schooling, smaller class sizes, and masking may have reduced the normal spread of RSV annually; that's absolutely a factor, but how much vs. any SARS-CoV-2 inate immunity change? That's still very interesting to dig into. | 22:55 |
| Tuvix | Is 'form cell aggregates with platelets' the driving factor behind the clotting observed then? | 22:55 |
| de-facto | if with each re-infection with COVID the probability increases that the innate immune reactions (including to other types of invaders or inflammations) would tend to become more thrombotic it could mean an ever increasing thrombosis risk, even from contaminations that before did not pose such a risk? | 22:59 |
| Tuvix | Worrying indeed as a possibility. It reminds me a bit of the frogs introduced in .au that upset the ecosystem's balance. | 23:01 |
| Tuvix | (or see any other similar examples of a 'novel' introduction that upsets a carefully crafted evolutionary balance.) | 23:01 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): @Marc_Veld @Rogier_de_Groot @C_Althaus The evolutionary rate of SARS-CoV2 is faster than for influenza - but mainly because of the saltational Omicron jump... twitter.com/trvrb/status/1… → https://twitter.com/TWenseleers/status/1610394496759390209 | 23:01 |
| de-facto | tbh i dont really know if the effects should be considered long lasting or not | 23:09 |
| de-facto | %title https://www.nature.com/articles/s41385-021-00482-8 | 23:32 |
| Brainstorm | de-facto: From www.nature.com: Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages | Mucosal Immunology | 23:32 |
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