| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Why hasn't Paxlovid implementation lived up to its expectations?Prescribed for only 13% in the US & 0.5% in the UK despite it working well against all variants to date, including XBB.1.5 [we've shown rebound is ~10% via systematic [... want %more?] → https://twitter.com/EricTopol/status/1610412081655984128 | 00:11 |
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| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Article in @Nature w important contribution to our understanding of how COVID can trigger clotting _and_ compromise our innate immune system to make us more vulnerable to secondary infections (look around you & re-think the myth that what you see is caused [... want %more?] → https://twitter.com/GANyborg/status/1610413536056086528 | 00:20 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): The authors found monocytes (immune cells) from C19 patients displayed a profound defect in pathogen sensing. The defect was also found when testing for secondary rhinovirus or bacterial infections. This may explain poor SARSCoV2 clearance & increased risk [... want %more?] → https://twitter.com/GANyborg/status/1610417068804898817 | 00:31 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Immunological dysfunction has also been found to last for a long time after acute COVID, also in mild and moderate disease. nature.com/articles/s4159… → https://twitter.com/GANyborg/status/1610422281972465664 | 00:50 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Although there’s much we still don’t know, in sum,the natural conclusion from all this is to expect the to see a large uptick in the no. & severity of ordinary infections such as the flu/RSV/rhinovirus after we are all infected w COVID [... want %more?] → https://twitter.com/GANyborg/status/1610424129324285952 | 00:59 |
| Brainstorm | New from Nature Vaccines: Jiayu Wang et al.: Omicron variant: a booster depending on infection histories → https://www.nature.com/articles/s41392-022-01279-2 | 01:09 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Covid misinformation spikes in wake of Damar Hamlin’s on-field collapse → https://old.reddit.com/r/Coronavirus/comments/102o7cg/covid_misinformation_spikes_in_wake_of_damar/ | 01:48 |
| Brainstorm | Updates for Bulgaria: +301 cases, +5 deaths, +6141 tests since a day ago — Slovakia: +252 cases since 14 hours ago | 02:09 |
| Tuvix | From the 2023 Nature paper, "[…] suggesting that Omicron infection is not a powerful natural booster against itself, especially for HCWs who were infected during the [original] wave." | 02:26 |
| Tuvix | ^ Seems fairly obvious from the data showing plenty of people readily infected with Omicron within the span of weeks. | 02:27 |
| Tuvix | But yet it's good to have actual data confirming these findings with more direct connection in terms of the immunity protection. Given Omicron makes up most of the current spread, catching doesn't really protect you all that well :\ | 02:28 |
| Tuvix | "In short, immune imprinting mediated by Wuhan Hu-1 significantly diminished the antibody responses against Omicron in HCWs [,Health Care Workers,] who were infected with Omicron." | 02:29 |
| Tuvix | Interesting; catching earlier varients may be a factor too; that's not ideal for people whose work or social practices put them more at risk. | 02:30 |
| LjL | oh | 02:36 |
| LjL | note to self (and maybe others): yesterday, or at this point the day before, there was a study posted on here on whether Moderna or Pfizer was eventually found to be better. I wanted to read it, but then I didn't. I still do, though. | 02:37 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Thanks to @______snc and @macroliter for pointing out that (1) XBB.1.5 is diverged enough from BA.2 that a BA.2 vax component wouldn't be that much better on XBB.1.5, and (2) BA.2's diffs from BA.5 were conserved with Wuhan so the Wuhan component of [... want %more?] → https://twitter.com/michaelzlin/status/1610458791841267712 | 03:14 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): That is the balance between breadth and strength was BA2+BA5 (or BA2.12+BA5 for a little more breadth), whereas Wuhan+BA5 sacrificed strength on extant strains for unnecessary breadth to extinct strains. → https://twitter.com/michaelzlin/status/1610460387685830656 | 03:24 |
| Brainstorm | Updates for New Zealand: +22740 cases since 17 hours ago — Pakistan: +22 cases, +2 deaths since 23 hours ago | 04:01 |
| Brainstorm | Updates for Rwanda: +113 cases, +1 deaths since 14 days ago | 05:03 |
| Brainstorm | Updates for Germany: +36145 cases, +307 deaths since a day ago | 06:05 |
| Brainstorm | Updates for New York, United States: +14423 cases, +72 deaths since a day ago — Virginia, United States: +12646 cases, +16 deaths since 6 days ago — Mississippi, United States: +5778 cases, +15 deaths since 7 days ago — Rhineland-Palatinate, Germany: +2675 cases, +27 deaths since a day ago | 07:07 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Students in Some Mass. School Districts Urged to Mask Up After Break: In an effort to keep flu and COVID cases down... The move is temporary and is only a suggestion, not a requirement → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/102wbvf/students_in_some_mass_school_districts_urged_to/ | 07:44 |
| Brainstorm | Updates for Taiwan: +33850 cases, +17 deaths, +42192 tests since 23 hours ago | 09:00 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | January 04, 2023: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/102xrmt/daily_discussion_thread_january_04_2023/ | 09:02 |
| Brainstorm | New from r/COVID19: COVID19: Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion → https://old.reddit.com/r/COVID19/comments/102xtvd/enhanced_transmissibility_of_xbb15_is_contributed/ | 09:11 |
| Brainstorm | Updates for Rajasthan, India: +15 cases since a day ago — West Bengal, India: +8 cases since a day ago — Gujarat, India: +8 cases since a day ago | 10:02 |
| Brainstorm | New from r/COVID19: COVID19: Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial → https://old.reddit.com/r/COVID19/comments/102ys6v/safety_and_immunogenicity_of_a_mosaic_vaccine/ | 10:27 |
| Brainstorm | New from StatNews: 3 challenges to watch in global health in 2023: As the third year of the Covid pandemic ends and we look to 2023, what can be spotted on the horizon? → https://www.statnews.com/2023/01/04/3-challenges-to-watch-in-global-health-in-2023/ | 10:57 |
| Brainstorm | Updates for France: +29 cases since 13 hours ago | 11:04 |
| -Bridgestorm- 🏠 Σεισμός! Earthquake! 5.9 Mb tremor, registered by alomax, occurred 34 minutes ago (09:38:40 UTC), during daytime, Lidoríki, Greece (38.59, 21.99), ↓12 km likely felt 250 km away by 454300 people (alomax.free.fr) | 11:13 | |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): To wrap up.Acute COVID-19:- results in monocyte recruitment, activation, differentiation- this, as expected, makes those monocytes less responsive- and those monocytes promote clotting, which may not be COVID-19-sepcific.And that is all. → https://twitter.com/Marc_Veld/status/1610579750371704834 | 11:16 |
| Brainstorm | New from BMJ: Healthcare workers must start documenting work related stress: Healthcare is becoming a task we are expected to complete to a standard that is not feasible with the means provided or compatible with our own moral welfare.1Combine this with the ever present threat from regulators that seem to have lost touch with [... want %more?] → http://www.bmj.com/content/380/bmj.p15.short | 12:43 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): For some nice summaries on what to expect from XBB.1.5, see threads below. twitter.com/EricTopol/stat… twitter.com/MoritzGerstung… → https://twitter.com/TWenseleers/status/1610604346651156480 | 12:52 |
| Brainstorm | Updates for Slovenia: +1903 cases since 17 hours ago | 13:09 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 04JAN22 → https://old.reddit.com/r/nCoV/comments/1032060/global_covid_cases_for_04jan22/ | 13:12 |
| Brainstorm | New from Reddit (test): Covid2019: Covid and mass formation psychosis → https://old.reddit.com/r/Covid2019/comments/1032pd1/covid_and_mass_formation_psychosis/ | 13:41 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Omicron was selected to avoid a lot of neutralising antibodies from previous immunity (infection and vaccination), so infection risk is high. But, as shown before, hybrid immunity is best.The population is predominant male, and also the ages do not allow extrapolation. → https://twitter.com/Marc_Veld/status/1610621522716286979 | 14:01 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): Some level of baseline genomic surveillance of variants coming from anywhere would be very good of course, as this would assist in adapting vaccines. Though much could still happen on the regulatory front & an agreement allowing continuous updating of [... want %more?] → https://twitter.com/TWenseleers/status/1610626484472844289 | 14:20 |
| Brainstorm | New from r/COVID19: COVID19: Global state of education-related inequality in COVID-19 vaccine coverage, structural barriers, vaccine hesitancy, and vaccine refusal: findings from the Global COVID-19 Trends and Impact Survey → https://old.reddit.com/r/COVID19/comments/1034e0c/global_state_of_educationrelated_inequality_in/ | 15:10 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): After our expert meeting with WHO yesterday, see the statement on COVID variants in China. Taking home messages: 1- Omicron lineages dominates (like elsewhere in the world), 2 - more data encouraged to be public. 3 - World needs to learn to work together [... want %more?] → https://twitter.com/Tuliodna/status/1610641106781208577 | 15:20 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): A lot will also depend on what further progress is made on the vaccine front, if anything will be done on the regulatory front to allow continuous updating of vaccines, what vaccination programs will be put in place in the long term & what vaccine uptake [... want %more?] → https://twitter.com/TWenseleers/status/1610641929959575552 | 15:29 |
| Brainstorm | Updates for Ireland: +6179 cases, +46 deaths since 13 days ago — Austria: +3776 cases, +18 deaths since 23 hours ago — Singapore: +1535 cases since 23 hours ago — Afghanistan: +61 cases since a day ago | 16:03 |
| Brainstorm | New from ClinicalTrials.gov: (news): Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness → https://clinicaltrials.gov/ct2/show/NCT05670444 | 17:08 |
| Brainstorm | New from ClinicalTrials.gov: (news): Microecology and Host Immunity in Patients With Severe COVID-19 Infection → https://clinicaltrials.gov/ct2/show/NCT05670275 | 17:17 |
| Brainstorm | New from ClinicalTrials.gov: (news): Cognitive Function Analysis and qEEG Study in Long COVID-19 Syndrome Patients → https://clinicaltrials.gov/ct2/show/NCT05670418 | 17:37 |
| Brainstorm | New from Politico: Belgium declares flu epidemic: The flu season kicked off early this year in Europe, increasing pressure on the health care sector. → https://www.politico.eu/article/flu-epidemic-belgium-health-sector-europe/ | 18:27 |
| mambang | %cases Malaysia | 18:27 |
| Brainstorm | mambang: Malaysia has had 5.0 million confirmed cases (15.4% of all people) and 36859 deaths (0.7% of cases; 1 in 888 people) as of 22 hours ago. 67.2 million tests were done (2.1 per capita, 7.5% positive). 26.0 million were vaccinated (79.5%). +333 cases, +1 deaths since a day ago. See https://covidnow.moh.gov.my/ | 18:27 |
| mambang | %cases singapore | 18:28 |
| Brainstorm | mambang: Singapore has had 2.2 million confirmed cases (38.7% of all people) and 1712 deaths (0.1% of cases; 1 in 3332 people) as of 2 hours ago. 24.8 million tests were done (4.3 per capita, 8.9% positive). 5.1 million were vaccinated (88.9%). +1535 cases since 23 hours ago. See https://offloop.net/covid19/?default=Singapore&legacy=no | 18:28 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Why the new COVID variant XBB.1.5 is taking over the U.S. so quickly: "We can prevent things from intensifying the same way we should be fighting all versions of the virus: masking, vaccinating & improving indoor [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/1039i41/why_the_new_covid_variant_xbb15_is_taking_over/ | 18:37 |
| Brainstorm | New from Contagion Live: Cyproheptadine Arm of COVID-19 Treatment Study Terminated: Due to negative results, the I-SPY COVID Trial is no longer evaluating cyproheptadine to treat critically ill COVID-19 patients. → https://www.contagionlive.com/view/cyproheptadine-arm-of-covid-19-treatment-study-terminated | 19:07 |
| Brainstorm | New from Politico: Coronavirus: New Covid strain is the most transmissible yet, WHO says → https://www.politico.com/news/2023/01/04/new-covid-strain-xbb-00076320 | 19:26 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Dear @EricTopol , we have seen the Spike mutation F486P mutation before also in a recombinant lineage in SA, my feeling is that XBB.1,5 with extra mutations is being overplayed given the level of population immunity in the world. twitter.com/erictopol/stat… → https://twitter.com/Tuliodna/status/1610710511783493658 | 19:55 |
| Brainstorm | New from COVID on Twitter: Theo Sanderson (@theosanderson): Much of this will be about changing volumes coming from different countries - e.g. the UK, which deposits ~all SARS-CoV-2 genomes openly, has seen a big fall in sequencing volume since that peak. → https://twitter.com/theosanderson/status/1610711472748871681 | 20:05 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Fla. surgeon general used ‘flawed’ vaccine science, faculty peers sayBut the University of Florida declined to discipline Joseph A. Ladapo, who is a tenured professor of medicine therewashingtonpost.com/education/2023… → https://twitter.com/Marc_Veld/status/1610715489591824385 | 20:15 |
| Brainstorm | New from StatNews: Senior WHO official faults China for undercounting Covid deaths: China is underreporting deaths from Covid-19 during its first big wave of infections, a senior WHO official said Wednesday. → https://www.statnews.com/2023/01/04/who-official-faults-china-undercounting-covid-deaths/ | 20:26 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccineJust a reminder: infections are not good and can cause issues.sciencedirect.com/science/articl… → https://twitter.com/Marc_Veld/status/1610719770403557379 | 20:36 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Covid-19 is still an urgent threat to public health. We must tackle vaccine inequity and hesitancy, write @JVLazarus et al in @bmj_latest twitter.com/bmj_latest/sta… → https://twitter.com/GANyborg/status/1610734533095063559 | 21:34 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Buffering of ACE2 affinity to enable future antibody escape is clearly important in SARS-CoV-2 evolution too (twitter.com/tylernstarr/st…), so will be interesting to see if this enables XBB.1.5 to tolerate future antibody escape mutations. → https://twitter.com/jbloom_lab/status/1610738873608593408 | 21:54 |
| Brainstorm | Updates for France: +14105 cases, +123 deaths since 10 hours ago | 22:04 |
| Brainstorm | New from Politico: Coronavirus: EU agrees on response to China’s COVID wave — but it’s not mandatory → https://www.politico.eu/article/eu-china-covid-pandemic-testing-countries-agree-menu-travel-measures-but-can-choose-to-opt-out/ | 22:33 |
| Brainstorm | Updates for Canada: +1171 cases, +6 deaths since a day ago | 23:06 |
| Brainstorm | New from The Atlantic: COVID Vaccines Aren’t Killing Athletes: During this week’s Monday Night Football game, the 24-year-old Buffalo Bills safety Damar Hamlin collapsed moments after making a routine defensive play. Hamlin seemed to have suffered a [... want %more?] → https://www.theatlantic.com/health/archive/2023/01/damar-hamlin-cardiac-arrest-covid-anti-vaccine-heart-theories/672644/ | 23:14 |
| Brainstorm | New from Contagion Live: us: What We Know About XBB.1.5, the New and Highly Contagious Omicron Subvariant → https://www.contagionlive.com/view/what-we-know-about-xbb-1-5-the-new-and-highly-contagious-omicron-subvariant | 23:24 |
| Brainstorm | New from COVID on Twitter: Jeremy Kamil @macroliter@mastodon.social (@macroliter): #Novavax would've been effective against the ancestral Dec 2019 Covid variant. But it's not gonna help much against the current swarm of #Omicron variants like #XBB15. If you haven't been infected or boosted in the past 6 months, [... want %more?] → https://twitter.com/macroliter/status/1610760735830986753 | 23:53 |
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