| Brainstorm | New from r/COVID19: COVID19: High-mortality Omi-S chimera from Omicron BA.1 Spike Protein and Ancestral SARS-Cov-19 backbone. 80% fatality in mice versus 0% with Omicron. Thoughts on this type of research? → https://old.reddit.com/r/COVID19/comments/y4xzd9/highmortality_omis_chimera_from_omicron_ba1_spike/ | 00:23 |
|---|---|---|
| Brainstorm | New from r/COVID19: COVID19: "Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron" Investigators in U.S. coupled Omicron BA.1 Spike protein to parental Covid-19 virus backbone. In mice, Omicron challenge caused mild disease & 0% fatality while Omi-S [... want %more?] → https://old.reddit.com/r/COVID19/comments/y514yz/role_of_spike_in_the_pathogenic_and_antigenic/ | 02:16 |
| Brainstorm | New from r/COVID19: COVID19: Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients → https://old.reddit.com/r/COVID19/comments/y53apq/plasma_metabolome_and_cytokine_profile_reveal/ | 03:03 |
| Brainstorm | New from r/Science: science: New study finds that monkeypox virus can spread widely within specialist hospital isolation rooms → https://old.reddit.com/r/science/comments/y54l8w/new_study_finds_that_monkeypox_virus_can_spread/ | 04:18 |
| Brainstorm | New from This Week In Virology: TWiV 946: Poo versus flu: Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans. → https://www.microbe.tv/twiv/twiv-946/ | 06:10 |
| Brainstorm | Updates for Germany: +2 cases since a day ago | 07:02 |
| Brainstorm | Updates for Metropolitana, Chile: +2074 cases, +6 deaths since 23 hours ago — New Jersey, United States: +2009 cases, +7 deaths since 23 hours ago — Sverdlovsk, Russia: +1102 cases since 23 hours ago — Maharashtra, India: +462 cases since 23 hours ago | 08:04 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | October 16, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/y5a36f/daily_discussion_thread_october_16_2022/ | 09:10 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: BQ.1.1 is among the most immune-evasive COVID variants yet. It's coming in hot in the U.S. → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/y5ay5q/bq11_is_among_the_most_immuneevasive_covid/ | 09:57 |
| Brainstorm | New from Reddit (test): CoronavirusUK: I’m sorry if this is a stupid question but I’m confused about a new type of lat. flow sent by the NHS - it says read results after 10 mins but not after 20. If it’s negative at 10 mins but then + at 11, do I ignore it or do I [... want %more?] → https://old.reddit.com/r/CoronavirusUK/comments/y5czkw/im_sorry_if_this_is_a_stupid_question_but_im/ | 12:27 |
| Brainstorm | New from COVID on Twitter: Florian Krammer (@florian_krammer): Ours is moving. Phase II in Mexico, Phase I in the US. But funding in the US for these vaccines is hard to find. twitter.com/EricTopol/stat… → https://twitter.com/florian_krammer/status/1581598170295209984 | 12:55 |
| Brainstorm | Updates for Malta: +28 cases since 23 hours ago | 13:09 |
| Brainstorm | New from NPR Science: Why did he suspect a COVID surge was coming? He followed the digital breadcrumbs: A theory about online candle reviews and COVID cases was put under the microscope, and has taken on new relevance amid concern at the lack of official data [... want %more?] → https://www.npr.org/2022/10/16/1128692167/yankee-candle-review-amazon-covid-twitter-study-covid19-pandemic-biden | 13:14 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): My article with Mark McClellan in Journal of the American Medical Association on the VALID Act - a major provision before Congress that modernizes FDA oversight of diagnostic tests, promoting safety and innovationHere’s why passage is [... want %more?] → https://twitter.com/ScottGottliebMD/status/1581607833052643328 | 13:33 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): While FDA affirmatively regulates commercial diagnostics, a growing percent of tests are offered without assurances they work. The stakes are rising. Tests are increasingly used to decide key care decisions. Concerns about accuracy of certain [... want %more?] → https://twitter.com/ScottGottliebMD/status/1581612797485813760 | 13:51 |
| Brainstorm | Updates for Hong Kong: +5564 cases, +5 deaths since a day ago | 13:59 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): FDA analyzed 125 EUA requests for COVID molecular diagnostics from labs, including AMC labs; found 66% weren’t designed or validated properly. Some were redesigned, revalidated; some removed from market. Inaccurate results could further disease [... want %more?] → https://twitter.com/ScottGottliebMD/status/1581614169782001664 | 14:01 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): AMCs should be part of VALID. Its risk-based model balances innovation with patient safety regardless of where test is made. It grandfathers existing LDTs and allows regulation of entities not just tests. Labs with good validation advance new [... want %more?] → https://twitter.com/ScottGottliebMD/status/1581616486795182091 | 14:11 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): VALID reflects at least 6 years of Congressional, FDA, stakeholder engagement. This is built on another decade-plus of FDA and stakeholders discussions around FDA oversight of tests made in labs. It addresses the significant public health need [... want %more?] → https://twitter.com/ScottGottliebMD/status/1581619151248191488 | 14:20 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): The new framework lets FDA oversee the process used to develop and validate tests rather than regulate only tests themselves. It’s a modern approach to regulation that looks at firms, not just individual tests, and gives patients assurance that [... want %more?] → https://twitter.com/ScottGottliebMD/status/1581620665236353024 | 14:30 |
| Brainstorm | New from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): No, not going to happen. Why not? Because neither a vaccine nor an infection can protect against infection for a lifetime! pic.twitter.com/hhsPDlX0qU → https://twitter.com/Marc_Veld/status/1581624261160366080 | 14:39 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 16OCT22 → https://old.reddit.com/r/nCoV/comments/y5g5xb/global_covid_cases_for_16oct22/ | 14:58 |
| ublx | %title https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1 | 14:59 |
| Brainstorm | ublx: From www.biorxiv.org: Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron | bioRxiv | 14:59 |
| ublx | To link to the above preprint, HackerNews borrowed from the abstract: "Researchers engineer SARS-CoV-2 Omicron variant with 80% mortality rate" (in mice) | 14:59 |
| Brainstorm | Updates for China: +5808 cases, +5 deaths since 20 hours ago | 15:01 |
| Brainstorm | New from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): That is clear: no needless nagging about i-m. vaccines that work very well more. Would she stick to it? pic.twitter.com/fFAaYy4H8D → https://twitter.com/Marc_Veld/status/1581630561562476544 | 15:07 |
| Brainstorm | New from r/COVID19: COVID19: Clinical studies of detecting COVID-19 from exhaled breath with electronic nose → https://old.reddit.com/r/COVID19/comments/y5h06g/clinical_studies_of_detecting_covid19_from/ | 15:45 |
| Brainstorm | New from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): NUcheckt: Government rightly claims that corona vaccine prevents virus spreadCorrect, enough data to show this. nu.nl/coronavirus/62… → https://twitter.com/Marc_Veld/status/1581658771985559552 | 17:01 |
| Brainstorm | New from r/COVID19: COVID19: A nationwide cohort study of the association of benzodiazepines with SARS-CoV-2 infection and clinical outcomes → https://old.reddit.com/r/COVID19/comments/y5izp5/a_nationwide_cohort_study_of_the_association_of/ | 17:10 |
| Brainstorm | New from r/COVID19: COVID19: Myocarditis in SARS-CoV-2 infection vs. COVID-19 vaccination: A systematic review and meta-analysis → https://old.reddit.com/r/COVID19/comments/y5k5ss/myocarditis_in_sarscov2_infection_vs_covid19/ | 17:58 |
| Brainstorm | Updates for Cuba: +7 cases since 23 hours ago | 18:01 |
| Brainstorm | New from COVID on Twitter: (translated) RP I 63 (@R___P__l63): @Marc_Veld Not protecting for life? Shall we start with vaccination against hepatitis B, for example, but also Rubella, polio, …. You're just bullshitting. → https://twitter.com/R___P__l63/status/1581676602425217025 | 18:27 |
| Brainstorm | New from COVID on Twitter: (translated) johan govaerts (@jgovaerts): @Marc_Veld @SchoofsLiliane Can you read? Of course, someone can get measles later in life, but someone who has had measles will not get measles a second time. Every mother knew that before the vaccine. The article in nature is about something else. → https://twitter.com/jgovaerts/status/1581681884287094784 | 18:36 |
| Brainstorm | Updates for Italy: +30238 cases, +32 deaths since a day ago | 19:04 |
| LjL | this... https://twitter.com/RougeMatisse/status/1581474804590579713 makes me very anxious | 19:59 |
| xx | LjL: that's been known since 6 months into covid. 2nd infection and more are worse. | 20:14 |
| xx | whereas people assumed than it's the other way round, me excluded | 20:14 |
| xx | people think they get some magic immunity if they get infected | 20:15 |
| xx | it's still a disease, it still has lasting effects after every time you get it | 20:16 |
| LjL | 6 months into covid most people were saying reinfections were so rare as to be basically non-existant. there were some reports from South Korea and that's about it | 20:16 |
| xx | and most people were wrong because it was just wishful thinking | 20:17 |
| LjL | by "most people" i also include the CDC and such | 20:18 |
| LjL | so you just can't say "that's been known" | 20:18 |
| xx | well CDC and WHO got almost everything wrong | 20:18 |
| LjL | maybe some people knew it, but that's not the meaning of passive "that's been known" | 20:18 |
| xx | well, fair, should have said that I've known it based on what could be observed happening | 20:19 |
| LjL | also look, even Topol who is the source of this thread says "Obviously these findings are worrisome since reinfection was quite rare before the Omicron wave hit, at 1% or less through the Delta variant wave" | 20:20 |
| LjL | %print https://twitter.com/EricTopol/status/1538202668451041280 | 20:23 |
| Brainstorm | LjL, It says: Eric Topol on Twitter: "How can you go from sequence of a novel virus to 2 vaccines with 95% efficacy and safety (>75,000 participants in RCT trials) in 10 months and not, in 2.5 years, go after pan-β-coronavirus and nasal vaccines with the same aggressive (OWS) template?" / Twitter | 20:23 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The @sporeMOHreport on the XBB variant wave moh.gov.sg/news-highlight……—Expects peak of 15,000 cases/d (>>BA.5 wave)—High % reinfections—"We have never declared that COVID-19 is an endemic disease, like some countries have"—Strongly advises to get [... want %more?] → https://twitter.com/EricTopol/status/1581712856914878466 | 20:29 |
| LjL | when i see this | 20:36 |
| LjL | There were 257,427 cohort participants with first SARS-CoV-2 infection and 38,926 participants who had SARS-CoV-2 reinfection (two or more infections); 5,396,855 participants with no record of positive SARS-CoV-2 infection were in the control group. Among those with reinfection, 36,417 (12.29%) people had two infections, 2,263 (0.76%) people had three infections, and 246 (.08%) people had four or more infections. | 20:36 |
| LjL | my question is, statistically, are people just about as likely to get re-infected as they are to get infected in the first place, or are those percentages showing the risk becomes lower? how much lower? | 20:36 |
| LjL | 0.05 0.15 0.62 0.10 | 20:38 |
| LjL | this is n_2inf / n_1inf and so on | 20:38 |
| LjL | or something like that | 20:38 |
| LjL | i'm not sure what it's telling me | 20:38 |
| Brainstorm | New from ##covid-19 Zotero group: Outcomes of SARS-CoV-2 Reinfection: Type Web Page URL https://www.researchsquare.com Date 2022-06-17 Extra DOI: 10.21203/rs.3.rs-1749502/v1 Accessed 2022-10-16 18:32:35 Language en Abstract First infection with SARS-CoV-2 is associated with increased risk of acute and post-acute [... want %more?] → https://www.zotero.org/groups/covid_links/items/J6453535 | 20:38 |
| LjL | more likely to get re-infected, except after three? | 20:39 |
| LjL | LjL unlikely to use a calculator correctly? | 20:39 |
| LjL | "The median distribution of time between the first and second infection was 79 days (IQR: 48–119), and between the second and third was 65 (43–97)" | 20:39 |
| LjL | these are pretty close in time | 20:39 |
| Brainstorm | New from r/COVID19: COVID19: Inactivation of SARS-CoV-2 and photocatalytic degradation by TiO2 photocatalyst coatings → https://old.reddit.com/r/COVID19/comments/y5ofq1/inactivation_of_sarscov2_and_photocatalytic/ | 20:57 |
| Brainstorm | New from r/Science: science: Vaccines to treat cancer possible by 2030, say BioNTech founders → https://old.reddit.com/r/science/comments/y5pv8e/vaccines_to_treat_cancer_possible_by_2030_say/ | 22:06 |
| de-facto | LjL, it was to be expected, we discussed it here so many times, introducing selection factors such as similar type of immunity (by either vaccine based on same variant or a wave of a certain variant) while permitting transmission are the perfect breeding ground for creating immuno-evasive variants (able to reinfect under such given circumstances), hence Omicron is no surprise | 22:12 |
| de-facto | btw the original variants seem to have included something that made them much more pathogenic, outside their spike protein | 22:13 |
| de-facto | ublx linked a paper above that describes implanting spike protein of an Omicron variant (that caused mild disease in mice) into the original D614G strain and it created a variant with 80% mortality or such | 22:14 |
| de-facto | so the spike was optimized very much for infection and immuno-evasion while for some reason the virus did not depend or profit from its pathogenicity, hence seems to have lost some of it | 22:15 |
| de-facto | %title https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1 | 22:15 |
| Brainstorm | de-facto: From www.biorxiv.org: Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron | bioRxiv | 22:15 |
| Brainstorm | New from COVID on Twitter: Tom Peacock (@PeacockFlu): slight tangent - would highly recommend northern hemisphere folk (and particularly their elderly relatives!) get the flu vaccine ASAP - looks like it could be a rough flu season after a couple of quiet years - the vaccine looks well matched for whats circulating [... want %more?] → https://twitter.com/PeacockFlu/status/1581740844285317121 | 22:25 |
| Brainstorm | Updates for Canada: +702 cases, +4 deaths since 23 hours ago | 23:06 |
| Brainstorm | New from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): Is early-onset cancer an emerging global epidemic? Current evidence and future implicationsIs cancer in young people an emerging global epidemic? Current Evidence and Future Implicationsnature.com/articles/s4157… → https://twitter.com/Marc_Veld/status/1581752276263534592 | 23:12 |
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