| de-facto | i am not entirely sure about this one, id guess if someone got a high level of antibodies (hence a high level of antibody producing b-cells active) exposure to a new (but similar enough) antigen will more likely ramp up the production of already existing kinds of antibodies, but if there are only few left it may also motivate more "new" b-cells to produce something that fits better to the new antigen | 00:01 |
|---|---|---|
| Timvde | I meant just after vaccination | 00:03 |
| Timvde | But you mean that when getting an adapted booster, it could be better to not be recently boosted with the original vaccine again? | 00:03 |
| de-facto | possibly | 00:03 |
| de-facto | its very complex, i am not entirely sure about this one | 00:04 |
| Timvde | Yes, of course, the immune system is very complex and we (as human race) don't understand every detail yet | 00:04 |
| Timvde | But that's an interesting take | 00:04 |
| de-facto | it would make some kind of sense from an evolutionary perspective | 00:05 |
| dTal | My curiosity is piqued by the qualification "as human race" - Timvde, are you a member of a secretive cabal that understands every detail of the human immune system? | 00:05 |
| Timvde | But I expect a new vaccination round to start by September or something (to prepare for the end of year wave), and I hope that we have updated vaccines then | 00:05 |
| Timvde | dTal: I cannot confirm nor deny that | 00:06 |
| dTal | o snap | 00:06 |
| de-facto | because if the immune system did just recently see an antigen (the reason for having high levels of antibodies) the pathogen most likely did not have much time for antigenic drift, but if it was long time ago (hence low level of antibodies) the pathogen most likely did accumulate quite some mutations since it was seen from the immune system | 00:06 |
| de-facto | the immune system would not know if its a "fake infection" (vaccination) or a real contamination | 00:07 |
| de-facto | so form the immune system perspective the assumption would be that the vaccination is pretty close to currently circulating pathogen | 00:07 |
| de-facto | something that does not really hold for employing Wuhan-Hu-1 (2 years old) for boosting against Omicron | 00:08 |
| Timvde | Ah, is that its official name? | 00:08 |
| Timvde | Because all the variants got Greek letters, but the original one didn't :P | 00:08 |
| de-facto | but i am not sure, thats just my speculation, i want to see updated signatures for vaccines though | 00:08 |
| de-facto | Timvde, i think its the name of the originally published sequence (from which the vaccines were derived) | 00:09 |
| Brainstorm | New from WebMD: No ‘Magic Moment’ to Lift COVID Restrictions: There is no “magic moment” for states to lift COVID-19 restrictions without a resulting rebound in COVID-related deaths, says a new study published in the Journal of the American Medical Association Health Forum. → https://www.webmd.com/lung/news/20220406/no-magic-moment-to-lift-covid-restrictions | 00:14 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The risk of blood clots (pulmonary embolism and DVT) and bleeding events with Covid: Country-wide data from Sweden indicates the heightened risk extends out to 6 months and occurs even with mild infections in first 30 days bmj.com/content/376/bm…@bmj_latest [... want %more?] → https://twitter.com/EricTopol/status/1511838420284313601 | 00:52 |
| Brainstorm | Updates for Brazil: +28965 cases, +394 deaths since 22 hours ago — France: +150954 cases, +117 deaths since 2 hours ago — Germany: +62349 cases, +547 deaths since 7 hours ago | 01:03 |
| Brainstorm | Updates for Canada: +13639 cases, +68 deaths since 23 hours ago — United Kingdom: +51530 cases since 20 hours ago | 02:05 |
| Brainstorm | New from WebMD: FDA to Decide by June on Future of COVID Vaccines: Top FDA official also says the fourth booster, authorized in March, was a stop gap measure. → https://www.webmd.com/vaccines/covid-19-vaccine/news/20220406/fda-to-decide-by-june-on-future-of-covid-vaccines-boosters | 02:20 |
| Brainstorm | Updates for Slovakia: +6057 cases since 15 hours ago — Italy: +720 deaths since 4 hours ago | 03:02 |
| Brainstorm | New from COVID on Twitter: Trevor Bedford (@trvrb): In this scenario, a vaccine update to Omicron should result in improvements to vaccine effectiveness against infection as well as to severe outcomes, regardless of whether the current vaccine is deemed to be working well enough or not well enough. 12/13 → https://twitter.com/trvrb/status/1511871624651304962 | 03:09 |
| Brainstorm | New from COVID on Twitter: Trevor Bedford (@trvrb): The more time that passes, the more confident we can be that another "Omicron-like" emergence won't occur from basal diversity, but manufacturing timelines will require a decision to be made soon if we are to have doses available ahead of a prospective fall/winter [... want %more?] → https://twitter.com/trvrb/status/1511871626006044674 | 03:18 |
| Brainstorm | New from Reddit (test): China_Flu: Israeli Study Shows 2nd Booster Efficacy Dwindles within 4 Weeks (Dr. Syed) → https://old.reddit.com/r/China_Flu/comments/ty1shx/israeli_study_shows_2nd_booster_efficacy_dwindles/ | 03:57 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Some quotes from Pfizer and FDA from the VRBPAC discussion today by CNN, for the record. Nice to see agreement that current formula is inadequate and that we should shoot for annual boosting.cnn.com/2022/04/06/hea… → https://twitter.com/michaelzlin/status/1511888823059329034 | 04:16 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): As we've seen before though, advisors can tend to be conservative to uphold a reputation for "rigor". Some VRBPAC members said they'd want clinical data for variant boosters, i.e. VE not just Ab levels. Yet FDA guidance already said Ab levels are [... want %more?] → https://twitter.com/michaelzlin/status/1511891593967505412 | 04:25 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Overall disappointing in that there was no plan. Today's question was "should we have a plan?" This should have been asked long ago. Even if original vax was okay for Delta after boosting, Omicron's divergence made new vax pressing. → https://twitter.com/michaelzlin/status/1511895657270808577 | 04:44 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): In the American pandemic the peak Covid ICU admissions was >26,000. Today that hit nearly 2,000, even lower than the June 2021 nadir at 4,000 #VaccinesWork Parenthetically, today is the 1st day Covid hospitalizations went up (by just 17) in >80 daysnewsnodes.com/us → https://twitter.com/EricTopol/status/1511897917300215814 | 04:54 |
| Brainstorm | Updates for Thailand: +26081 cases, +91 deaths since a day ago | 05:07 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): “Shanghai Residents Plead for Help Online as Daily Covid-19 Count Nears 20,000” - WSJ“Nearly a week into lockdown, many turn to social media to get food, medicine or, if they are taken away for quarantine, advice on pet care.” wsj.com/articles/shang… → https://twitter.com/ScottGottliebMD/status/1511903716814864384 | 05:13 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): And @trvb who gave a presentation on the speed of SARSCoV2 evolution in the spike gene at VRBPAC, states strongly that matching to existing strains (i.e. Omicron) is necessary to get the vaccine efficacy we needtwitter.com/trvrb/status/1… → https://twitter.com/michaelzlin/status/1511918306474663944 | 06:11 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): He adds the same points I and others have made before: matching the immunogen to that of the virus you're trying to prevent will certainly improve the vaccine. And there's data as well (same mouse study I cited elsewhere). pic.twitter.com/tKtw8qUzyY → https://twitter.com/michaelzlin/status/1511919803736289285 | 06:20 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): 2022.03.28: Explaining why, after 2 shots of ancestral vax, a 3rd shot of Omicron only gives a slightly better response to Omicron ("not significantly different") than a 3rd shot of ancestral vax. It's because immune systems, like ships, are slow to [... want %more?] → https://twitter.com/michaelzlin/status/1511922250236133378 | 06:30 |
| Brainstorm | Updates for Germany: +201729 cases since 13 hours ago | 07:06 |
| Brainstorm | New from Science-Based Medicine: Federal employment rights agency inundated with thousands of COVID-related discrimination claims: Thousands of workers have filed complaints with the EEOC alleging COVID-related employment discrimination. It may [... want %more?] → https://sciencebasedmedicine.org/federal-employment-rights-agency-inundated-with-thousands-of-covid-related-discrimination-claims/ | 07:08 |
| Brainstorm | Updates for Unknown, China: +24421 cases since a day ago — Berlin, Germany: +13028 cases, +10 deaths since a day ago — Queensland, Australia: +10971 cases, +7 deaths since a day ago — Tokyo, Japan: +8652 cases, +6 deaths since a day ago | 08:02 |
| Brainstorm | New from MedicineNet: (news): National Push for Long COVID Research → http://www.medicinenet.com/script/main/art.asp | 08:15 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | April 07, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/ty794p/daily_discussion_thread_april_07_2022/ | 09:03 |
| Brainstorm | Updates for Taiwan: +531 cases, +65581 tests since a day ago | 10:01 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): In reality, with a CFR similar to that seen in Hong Kong, it would likely amount to several million Covid deaths. Anyone aware of age-structured case & hospitalisation data for China? → https://twitter.com/TWenseleers/status/1511989983917314054 | 10:58 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): So this v solid paper is a big deal. Here’s the evidence you need to go vaccinate your kid right now. From this, subsequent SARS-CoV-2 infection in unvaccinated may give more severe outcomes due to antibody-dependent infection of monocytes (immune cells) [... want %more?] → https://twitter.com/GANyborg/status/1511994461215244289 | 11:17 |
| Brainstorm | New from Politico: Central banks: ECB’s Christine Lagarde tests positive for COVID-19 → https://www.politico.eu/article/ecbs-christine-lagarde-tests-positive-for-covid-19/ | 11:27 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Macrophages (another type of immune cell) in the lungs were also infected. A new preprint also report similar findings; that these immune cells can be infected with SARS-CoV-2 & trigger an extensive inflammatory response that contributes to severe COVID-19 [... want %more?] → https://twitter.com/GANyborg/status/1512000197701820419 | 11:37 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): This also opens for better drugs & choosing the best preparations of convalescent patient plasma and monoclonal antibodies for therapy. Both studies are described here: nature.com/articles/d4158… → https://twitter.com/GANyborg/status/1512003149699198982 | 11:46 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Conclusion: To let the virus rip before everyone, including kids, are vaccinated, and before we know more about the mechanisms described here is not only unethical but comes with a clear risk of backlash.Time to change policies. And:GET [... want %more?] → https://twitter.com/GANyborg/status/1512005203633053701 | 11:56 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): And not to start a new thread, but I must remind of all the ways transmission of this virus can be controlled in highly vaccinated populations _without_ the use of restrictions/lockdowns: Mass testing!In comb w Ventilation+Air Filtering & masks if [... want %more?] → https://twitter.com/GANyborg/status/1512006942113374209 | 12:05 |
| Brainstorm | New from COVID on Twitter: Long Covid Advocacy (@LongCovidAdvoc): @VirusesImmunity on the status of trials for #Paxlovid for #LongCovid It's a Great Idea Trying to promote initiation of randomised placebo controlled clinical trials Pharma companies @pfizer not convinced Can Patient Power [... want %more?] → https://twitter.com/LongCovidAdvoc/status/1512007911060512768 | 12:35 |
| Brainstorm | New from Pfizer: Pfizer to Acquire ReViral and Its Respiratory Syncytial Virus Therapeutic Candidates: Anonymous (not verified) Thu, 04/07/2022 - 06:45 Thursday, April 07, 2022 - 06:45am Proposed acquisition strengthens Pfizer’s capabilities in [... want %more?] → https://www.pfizer.com/news/press-release/press-release-detail/pfizer-acquire-reviral-and-its-respiratory-syncytial-virus | 12:55 |
| Brainstorm | New from BBC Health: NHS under huge strain as A&Es turn away ambulances: Winter pressures being felt in spring, as Covid cases remain high and other illnesses rebound. → https://www.bbc.co.uk/news/health-61023908 | 13:15 |
| Brainstorm | New from ECDC: Data on testing for COVID-19 by week and country: Data in multiple file formats with information about testing volume for COVID-19, sorted by week and country, and updated on a weekly basis. → https://www.ecdc.europa.eu/en/publications-data/covid-19-testing | 13:34 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 07APR22 → https://old.reddit.com/r/nCoV/comments/tyboa4/global_covid_cases_for_07apr22/ | 14:12 |
| Brainstorm | New from Politico: German parliament rejects mandatory coronavirus vaccination: The vote marks a painful defeat for Chancellor Olaf Scholz and Health Minister Karl Lauterbach. → https://www.politico.eu/article/german-parliament-rejects-mandatory-coronavirus-vaccination/ | 15:04 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Low-income Part D beneficiaries without subsidies often don’t fill scripts; Pfizer strikes a deal for RSV drugs → https://www.statnews.com/pharmalot/2022/04/07/medicare-alzheimers-pfizer-insulin-biosimilars-merck/ | 15:24 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Insulin lispro Sanofi, insulin lispro, Diabetes Mellitus, Date of authorisation: 19/07/2017, Revision: 7, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/insulin-lispro-sanofi | 15:34 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Protection of the aged and type of vaccine used pic.twitter.com/2tGEfd91rU → https://twitter.com/EricTopol/status/1512065880259145748 | 16:04 |
| Brainstorm | New from r/COVID19: COVID19: Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study → https://old.reddit.com/r/COVID19/comments/tye0ms/risks_of_deep_vein_thrombosis_pulmonary_embolism/ | 16:23 |
| Brainstorm | New from ClinicalTrials.gov: COVID-19 Testing in Underserved and Vulnerable Populations: Conditions : Heart Failure; Coronary Artery Disease; Cancer; Chronic Kidney Diseases; COPD; Obesity; Sickle Cell Disease; Diabetes Mellitus, Type 2 → https://clinicaltrials.gov/ct2/show/NCT05315908 | 17:03 |
| Brainstorm | New from ClinicalTrials.gov: (news): Reactogenicity, Immunogenicity and Inflammatory Response by New COVID-19 Vaccine Platforms → https://clinicaltrials.gov/ct2/show/NCT05315856 | 17:13 |
| Brainstorm | New from ClinicalTrials.gov: (news): Clinical Use of EVUSHELD as Pre-exposure Prophylaxis in Real-world Setting in Gulf Cooperation Council Countries → https://clinicaltrials.gov/ct2/show/NCT05315323 | 17:23 |
| Brainstorm | New from ClinicalTrials.gov: (news): Establishing Immunogenicity and Safety of Needle-free Intradermal Delivery of mRNA COVID-19 Vaccine → https://clinicaltrials.gov/ct2/show/NCT05315362 | 17:32 |
| Brainstorm | New from ClinicalTrials.gov: (news): Neutralizing Power of Anti-SARS-CoV-2 Serum Antibodies → https://clinicaltrials.gov/ct2/show/NCT05315583 | 17:42 |
| Brainstorm | Updates for Netherlands: +12867 cases, +9 deaths since 20 hours ago — Germany: +184598 cases, +350 deaths since 23 hours ago | 18:10 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): How we avoid full immune escape from Omicron: the role of memory B cells after mRNA vaccination, enough to fend off but shows how our response is strained cell.com/immunity/fullt… @ImmunityCP pic.twitter.com/BkBNyg4MJR → https://twitter.com/EricTopol/status/1512099454156869635 | 18:11 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): @theosanderson @jcbarret @ZaminIqbal Would be interested in a poll of what circulating variant would be most likely 1 or 2 years from now - a descendant of Omicron, of Delta, of Alpha, a recombinant, or something else... What do you reckon? → https://twitter.com/TWenseleers/status/1512100379009458183 | 18:21 |
| Brainstorm | New from COVID on Twitter: Trevor Bedford (@trvrb): @michaelzlin For H3N2 flu where we have >50 years of evolution, we don’t see returns to previously observed antigenic phenotypes (bedford.io/papers/bedford…). This suggests at least for H3N2 a large shape space that can still function. I don’t see an obvious [... want %more?] → https://twitter.com/trvrb/status/1512103221975605251 | 18:31 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The US BA.2 variant wave leader states watch, log-plotNone are above 24 new cases/100,000 residentsNo sign of any surge or rapid ascent like BA.1/BA 1.1 that got up to >300/100,000 pic.twitter.com/DfSOWc223a → https://twitter.com/EricTopol/status/1512109731413778448 | 18:50 |
| Brainstorm | Updates for Italy: +70123 cases since 20 hours ago | 19:00 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): In China over 52M people aged 60 and older have yet to be vaccinated with any COVID vaccineBooster rates are also low. Only 56.4% of people age 60-69 have received a booster. 48.4% of people 70-79Yet there doesn't appear to be *large scale* [... want %more?] → https://twitter.com/ScottGottliebMD/status/1512119588313522187 | 19:29 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Omicron infections soon after Delta, another reflection of its immune evasive property, report of 10 such cases New @CDCMMWR cdc.gov/mmwr/volumes/7… pic.twitter.com/meuadnbHCD → https://twitter.com/EricTopol/status/1512123935919202332 | 19:48 |
| Brainstorm | New from Medical Xpress: Diseases, Conditions, Syndromes: Researchers help develop highly accurate, 30-second coronavirus test → https://medicalxpress.com/news/2022-04-highly-accurate-second-coronavirus.html | 20:07 |
| Brainstorm | Updates for Japan: +53499 cases, +69 deaths since 13 hours ago — United Kingdom: +48875 cases, +322 deaths, +574176 tests since 23 hours ago — Canada: +44 deaths since 21 hours ago — France: +150965 cases since 22 hours ago | 20:09 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): PCR testing has not significantly changed since the beginning of the BA.2 wave (and it's too low). Recent test positivity (national) has increased to 3.5% pic.twitter.com/TaAP9dR67B → https://twitter.com/EricTopol/status/1512135522235273220 | 20:36 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Some progress toward preventive cancer vaccines for people at increased risk, even multicancer/universal cancer vaccines. A feature @ScienceMagazine science.org/doi/10.1126/sc… by @jocelynkaiser pic.twitter.com/twwWfGi71m → https://twitter.com/EricTopol/status/1512138519413620737 | 20:46 |
| Brainstorm | New from WebMD: Capitol Hill Fox That Bit 9 People Tests Positive for Rabies: The fox on Capitol Hill responsible for biting at least nine people tested positive for rabies after being euthanized Wednesday. → https://www.webmd.com/a-to-z-guides/news/20220407/capitol-hill-fox-that-bit-9-people-tests-positive-for-rabies | 21:06 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The BA.2 | sign in China, as it breaks through lockdowns pic.twitter.com/Wrl0UW5Fzr → https://twitter.com/EricTopol/status/1512157788859891718 | 22:04 |
| Brainstorm | New from CIDRAP: COVID patients may be at higher risk for blood clots for up to 6 months: Mary Van Beusekom | News Writer | CIDRAP News Apr 07, 2022 Risk rose within 70 days for deep vein thrombosis and 110 days for pulmonary embolism. → https://www.cidrap.umn.edu/news-perspective/2022/04/covid-patients-may-be-higher-risk-blood-clots-6-months | 22:24 |
| Brainstorm | New from NPR Science: Why hasn't my daughter caught COVID? 2 factors likely protect her — and maybe you, too: My 6-year-old has been exposed to SARS-CoV-2 at least 4 times and never tested positive. Lots of people fall into that [... want %more?] → https://www.npr.org/sections/goatsandsoda/2022/04/07/1091466181/why-hasnt-my-daughter-caught-covid-2-factors-likely-protect-her-and-maybe-you-to | 22:44 |
| Brainstorm | New from CIDRAP: Study: About two thirds of Africans exposed to COVID-19: Lisa Schnirring | News Editor | CIDRAP News Apr 07, 2022 The true number of African cases might be 98 times higher than official numbers. → https://www.cidrap.umn.edu/news-perspective/2022/04/study-about-two-thirds-africans-exposed-covid-19 | 23:22 |
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