| IndoAnon | Pfizer, sinovac, and Azn | 00:00 |
|---|---|---|
| Brainstorm | New from Reddit (test): Don't Vax On Me!: submitted by /u/shallah to r/CoronaVirus_2019_nCoV → https://is.gd/YWTiEx | 00:06 |
| nixonix | 100 mcg pfizer was a bit worse than 30. maybe sweet spot with it would be somewhere between 50 and 75? supposedly better codone optimization than moderna, but apparently optimized for saving synthesized mrna instead of maximal titers with higher doses | 00:11 |
| nixonix | .title https://www.nature.com/articles/s41586-020-2639-4 | 00:11 |
| Brainstorm | nixonix: From www.nature.com: Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults | Nature | 00:11 |
| nixonix | and moderna got like half the titers of 100 mcg with just quarter dose. makes you wonder if moderna is better optimized after all... | 00:13 |
| nixonix | .title https://twitter.com/CellDeathLab/status/1428393845855768576 | 00:27 |
| Brainstorm | nixonix: From twitter.com: Kristopher Sarosiek (@CellDeathLab): "We stained for ACE2 (#SARSCoV2 entry receptor) in over 100 human lung specimens and found that while ACE2 expression generally increases with age, it's incredibly [...] | 00:27 |
| Brainstorm | New from r/WorldNews: worldnews: World leaders return to U.N. with focus on pandemic, climate → https://is.gd/awydSZ | 01:10 |
| nixonix | "our recent analyses suggests that affinity maturation, over months, of SARS-CoV-2 neutralizing antibodies in convalescents confers additional flexibility and affinity24,25,27 that may not be afforded by standard mRNA vaccine regimens28. Indeed, individual affinity-matured antibodies can impose a requirement for multiple viral substitutions for | 01:26 |
| nixonix | antibody escape and enable substantial activity against VOC | 01:26 |
| nixonix | "affinity maturation, the availability of numerous epitope targets and the generation of high levels of circulating antibodies may explain why polyclonal plasma from individuals who have been both infected and subsequently vaccinated could effectively neutralize the otherwise highly neutralization resistant PMS20 spike, as well as sarbecoviruses | 01:28 |
| nixonix | whose NTD and/or RBD domains are divergent from SARS-CoV-2 | 01:28 |
| nixonix | those PMS something are their chimeric viruses or spikes, that had several substitutions collected from different variants | 01:29 |
| nixonix | .title https://www.biorxiv.org/content/10.1101/2021.08.06.455491v1.full | 01:29 |
| Brainstorm | nixonix: From www.biorxiv.org: High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies | bioRxiv | 01:29 |
| nixonix | so if using longer intervals doesnt result much higher circulating ab titers than using standard interval, but protection vs hospitalization wanes slower, it may be because of improved affinity maturation of germinal center b-cells. that team seems to believe its beneficial | 01:31 |
| nixonix | cant be about killer t-cells, because i remember their numbers were a bit lower with longer intervals | 01:32 |
| nixonix | source who claimed this isnt clear: "But timing is key when it comes to additional doses, whichever vaccine is given. Researchers say that exact right interval when immune response has matured -- but before protection begins to wane -- is the ideal target. | 01:35 |
| nixonix | "What we have seen is that waiting six months does mount a better immune response later," he added. "It seems that our immune system likes to rest and develop antibodies, and then mount a stronger response when it sees the same pathogen again later on." | 01:35 |
| nixonix | .title https://abcnews.go.com/Health/covid-19-hybrid-immunity-potential-pandemic-game-changer/story?id=79941607 | 01:36 |
| Brainstorm | nixonix: From abcnews.go.com: How COVID-19 hybrid immunity could be a potential pandemic game-changer - ABC News | 01:36 |
| Brainstorm | New from r/WorldNews: worldnews: Almost 90% of people in India's financial capital have COVID-19 antibodies: survey → https://is.gd/4DVVKd | 01:52 |
| Brainstorm | Updates for Bermuda: +259 cases (now 4477), +4 deaths (now 42), +6521 tests (now 516625) since 18 hours ago | 02:30 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Delta can be daunting to contain.The situation in Singapore with over 1,000 new cases today and yesterday, 80% of total population fully vaccinated, 1 of top 3 countries in the world, is an important indicator of the challenge. pic.twitter.com/zKHYUcn3gV → https://is.gd/qDcp9W | 02:45 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Unlike Israel, Singapore was not a 1st mover, less proportion has waned, attained ~20 per cent points higher fully vaccinated population. Far less natural infection immunityIsrael: 100% PfizerSingapore: Pfizer/Moderna, AFAIK spacing by protocolhttps:// ig.ft.com/coronavirus-va… pic.twitter.com/v137sfsOso → https://is.gd/idwR3C | 03:38 |
| Brainstorm | Updates for Ecuador: +21 cases (now 505881), +29263 tests (now 1.8 million) since 19 hours ago | 04:10 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Correction: That ranking lost is for % of 1 or more doses, not fully vaccinated. → https://is.gd/DhHvjq | 04:10 |
| Brainstorm | New from r/WorldNews: worldnews: Big gap between Pfizer, Moderna vaccines seen for preventing COVID hospitalizations → https://is.gd/tVYsuP | 04:32 |
| Brainstorm | Updates for South Korea: +1605 cases (now 287536), +5 deaths (now 2409), +30477 tests (now 14.1 million) since 20 hours ago — Australia: +692 cases (now 86320), +2 deaths (now 1164), +192822 tests (now 35.8 million) since 20 hours ago | 04:35 |
| Brainstorm | New from The Indian Express: World: Fighting a pandemic, While launching Africa’s health revolution → https://is.gd/weosKb | 06:17 |
| Brainstorm | New from The Indian Express: World: Climate, COVID and Biden’s challenged credibility underline UN’s big week → https://is.gd/ho9Y1c | 06:38 |
| Brainstorm | New from The Indian Express: World: When Covid-19 stole their smell, these experts lost much more → https://is.gd/hYc9lA | 07:20 |
| Brainstorm | Updates for United Kingdom: +4458 cases (now 7.4 million) since 23 hours ago — Lombardy, Italy: +348 cases (now 879639), +1 deaths (now 33982) since 23 hours ago — Bermuda, United Kingdom: +259 cases (now 4477), +4 deaths (now 42) since 23 hours ago — New Caledonia, France: +130 cases (now 3531), +6 deaths (now 22) since 23 hours ago | 07:29 |
| Brainstorm | Updates for India: +30256 cases (now 33.5 million) since a day ago | 08:31 |
| Brainstorm | New from Reddit (test): China_Flu: Hospital heads warn shortage in ECMO machines could spell death for critical COVID patients → https://is.gd/IVBx2F | 08:34 |
| Brainstorm | New from r/WorldNews: worldnews: Fresh calls for windfall tax on companies that prospered during Covid → https://is.gd/en8zBT | 08:44 |
| Brainstorm | New from r/WorldNews: worldnews: They Shunned COVID-19 Vaccines but Embraced Antibody Treatment → https://is.gd/JdU83J | 08:55 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | September 20, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/GnvISB | 09:06 |
| Brainstorm | New from Science-Based Medicine: The dumpster diving VAERS preprint debacle: How did we get here?: Last week, SBM devoted a lot of digital ink to a poorly done study analyzing the VAERS database for myocarditis after COVID-19 vaccination that was widely publicized to imply that the vaccine is more dangerous than the disease. Three out of the four [... want %more?] → https://is.gd/tLLK5O | 09:16 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): Since May over 100,000 Americans lost their lives because of their choice not to get vaccinated. In this way, the death toll of the pandemic for the US in terms of confirmed Covid deaths may well reach 1 million by the end of the year. Sad... twitter.com/PeterHotez/sta… → https://is.gd/aYBjg5 | 09:27 |
| Brainstorm | Updates for New Caledonia: +72 cases (now 3603), +3 deaths (now 25) since 20 hours ago | 10:35 |
| Brainstorm | New from StatNews: Winter is coming, again: What to expect from Covid-19 as the season looms: STAT spoke with infectious disease experts and others about what to expect from Covid-19 as the seasons change. → https://is.gd/66mk0q | 10:41 |
| Brainstorm | New from r/Science: science: Drug-resistant infections have increased in hospitals during the pandemic. methicillin-resistant Staphylococcus aureus, or MRSA —rose 34 percent after having fallen in the first quarter of 2020 as compared to the same period a year earlier. → https://is.gd/ahhx81 | 10:51 |
| Brainstorm | New from EMA: What's new: Orphan: Orphan designation: Recombinant human IgG1 kappa light chain monoclonal antibody targeting plasma kallikrein (lanadelumab), Treatment of hereditary angioedema, 09/10/2015, Positive → https://is.gd/ic3po1 | 11:23 |
| Brainstorm | Updates for Russia: +19744 cases (now 7.3 million), +778 deaths (now 198996), +840071 tests (now 187.0 million) since 21 hours ago — Israel: +4952 cases (now 1.2 million), +265898 tests (now 20.7 million) since 15 hours ago — Germany: +4259 cases (now 4.2 million) since 22 hours ago | 11:37 |
| sdfgsdfg | I can't even get a haircut without a vaccine... I feel like a cornered animal | 11:44 |
| sdfgsdfg | any new concerning academic papers on mrna vaccine safety ? | 11:45 |
| Brainstorm | New from COVID tweets: Edouard Mathieu (@redouad): Most COVID-19 vaccinations in the last week:🇨🇺 Cuba 13.9% of the population🇮🇷 Iran 9.2%🇳🇿 New Zealand 7.9%🇦🇺 Australia 7.6%🇧🇳 Brunei 6.9%🇹🇭 Thailand 6.3%🇰🇭 Cambodia 6.2%🇻🇳 Vietnam 6%🇧🇷 Brazil 5.5%🇦🇪 UAE 5%ourworldindata.org/covid-vaccinat… → https://is.gd/CKPME4 | 11:45 |
| sdfgsdfg | come on guys | 11:45 |
| sdfgsdfg | if all countries properly locked down we could end this shit in 2 weeks | 11:46 |
| dTal | sdfgsdfg: what's wrong with the old papers? | 11:58 |
| dTal | just get the damn vaccine | 11:58 |
| sdfgsdfg | couldn't find anything concerning in the old papers. It's been in use for only 4 years so far | 11:58 |
| dTal | Everyone I know has the vaccine and we're all fine | 11:58 |
| sdfgsdfg | for now ? | 11:58 |
| sdfgsdfg | you'll start getting breakthrough infections soon enough | 11:59 |
| sdfgsdfg | are you planning on getting the vaccine every 6 months ? | 11:59 |
| dTal | Yeah, one of my friends got vaxxed really early, and she had a breakthrough infection | 11:59 |
| dTal | no, I won't be offered it | 12:00 |
| dTal | if I could get a booster for the latest variant every 6 months you bet your ass I'd get it | 12:01 |
| sdfgsdfg | close to 6 month mark you'll always be at risk | 12:01 |
| dTal | That doesn't seem like much of an argument to not get vaccinated | 12:02 |
| sdfgsdfg | I'll downplay it into valhalla | 12:04 |
| sdfgsdfg | lol | 12:04 |
| dTal | I don't know why you'd not get vaccinated. There's no known mechanism by which you could suddenly suffer side effects months down the line. The vaccine and all the spike proteins are cleared out in a matter of weeks, and you're left only with the immune memory. There's some tiny risk of blood clotting, which is strictly less than the risk from covid itself, but if you avoid that you're golden. | 12:05 |
| Brainstorm | New from The Indian Express: World: Canada votes in pandemic election that could cost Justin Trudeau → https://is.gd/2O2iP1 | 12:06 |
| dTal | I can't imagine *wanting* to get a haircut without a vaccine. You're sitting in a chair while a stranger breathes down your neck for half an hour. A stranger who spends their days in intimate contact with other strangers. | 12:07 |
| Brainstorm | New from StatNews: Pfizer Covid-19 vaccine generates robust antibody response in children, without serious safety issues, company says: Pfizer and its partner BioNTech said they would file for authorization of their Covid-19 vaccine for use in children after clinical trial results showed encouraging antibody levels in volunteers. → https://is.gd/Q5QoZ7 | 12:49 |
| lastshell | sdfgsdfg how old are you ? | 13:03 |
| sdfgsdfg | 31 | 13:03 |
| lastshell | im 37 got pfizer 2shots no issues | 13:04 |
| lastshell | my cousing is 27 and he got moderna no issues at all just arm same with me arm pain is ok | 13:05 |
| lastshell | dont trust facebook for medical advise my 2 cents | 13:07 |
| Brainstorm | New from NPR: Pfizer And BioNTech Vaccine Trials For Kids Show The Shots Are Safe And Effective: Pfizer and BioNTech's trials for the COVID-19 vaccine for children under 12 showed the shots are safe for children and establish a strong antibody response against the virus. → https://is.gd/0JI4Yn | 13:11 |
| de-facto | .title https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-announce-positive-topline-results-pivotal | 13:15 |
| Brainstorm | de-facto: From investors.biontech.de: Pfizer and BioNTech Announce Positive Topline Results from Pivotal Trial of COVID-19 Vaccine in Children 5 to 11 Years | BioNTech | 13:15 |
| Brainstorm | New from The Indian Express: World: Pfizer Covid-19 shot safely bolsters antibodies in kids aged 5 to 11 → https://is.gd/Q7qEDY | 13:22 |
| lastshell | The trial included 2,268 participants ages 5 to 11 and used a two-dose regimen of the vaccine administered 21 days apart. This trials used a 10-microgram dose -- smaller than the 30-microgram dose that has been used for those 12 and older. | 13:24 |
| Brainstorm | New from BBC Health: Pfizer/BioNTech jab safe for children aged five to 11: The positive trial results could pave the way for vaccinating children younger than 12, if approved. → https://is.gd/xS7DCp | 13:54 |
| Brainstorm | Updates for Romania: +3342 cases (now 1.2 million), +78 deaths (now 35592), +56575 tests (now 12.3 million) since 23 hours ago — Nepal: +975 cases (now 785541), +8 deaths (now 11048) since 23 hours ago — UAE: +313 cases (now 733003), +2 deaths (now 2077), +596177 tests (now 80.9 million) since 23 hours ago | 14:00 |
| Brainstorm | New from r/WorldNews: worldnews: Pfizer says its COVID vaccine works in children aged 5-11, seeks FDA approval → https://is.gd/F2yNcH | 14:04 |
| MerlinMp[m] | <dTal> "I can't imagine *wanting* to get..." <- You have poor imagination. There are people who had mild covid recently. Why they should be affraid of haircut? | 14:25 |
| dTal | they shouldn't! | 14:26 |
| Brainstorm | New from BBC Health: Covid vaccination begins for UK 12 to 15 year olds: It is part of the drive to get more people protected ahead of winter as the pandemic continues. → https://is.gd/Fo3OrT | 14:37 |
| Brainstorm | Updates for Switzerland: +1342 cases (now 824420), +108675 tests (now 10.5 million) since a day ago — Grenada: +236 cases (now 4077), +5 deaths (now 55) since a day ago — Faroe Is.: +3 cases (now 1070), +1000 tests (now 422000) since 12 hours ago — Gibraltar: +2 cases (now 5479), +899 tests (now 352305) since a day ago | 14:38 |
| Brainstorm | New from r/WorldNews: worldnews: Pfizer/BioNTech data shows COVID-19 vaccine safe and protective in kids → https://is.gd/Ogv1cu | 14:58 |
| Brainstorm | Updates for Denmark: +2 deaths (now 2630), +94431 tests (now 83.0 million) since 22 hours ago | 15:03 |
| Brainstorm | New from r/Science: science: Pfizer and BioNTech Announce Positive Topline Results From Pivotal Trial of COVID-19 Vaccine in Children 5 to 11 Years → https://is.gd/ktFyYD | 15:09 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Key Senate panel proposes expanded pharma pricing penalties; Biden will urge Covid-19 summit to help poor nations get vaccines → https://is.gd/6C39Ps | 15:31 |
| Brainstorm | Updates for Qatar: +139 cases (now 235626), +10922 tests (now 2.6 million) since 18 hours ago — Germany: +3937 cases (now 4.2 million) since 22 hours ago | 15:40 |
| Brainstorm | New from r/WorldNews: worldnews: Brazil’s Unvaccinated Far-Right President Bolsonaro Forced to Eat Pizza on the Street in NYC → https://is.gd/6pPIVc | 15:42 |
| Brainstorm | New from EMA: What's new: PIP: Opinion/decision on a Paediatric investigation plan (PIP): Chimeric fibril-reactive IgG1k monoclonal antibody 11-1F4, decision type: , therapeutic area: , PIP number: P/0449/2020 → https://is.gd/81XH7g | 15:53 |
| Brainstorm | New from Pfizer: Pfizer Invites Public to Listen to Webcast of Pfizer Discussion at Healthcare Conference: Anonymous (not verified) Mon, 09/20/2021 - 10:00 Monday, September 20, 2021 - 10:00am NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: PFE) invites investors and the general public to listen to a webcast of a discussion with Albert Bourla, Chairman [... want %more?] → https://is.gd/XQZObG | 16:14 |
| Brainstorm | Updates for Bangladesh: +1555 cases (now 1.5 million), +26 deaths (now 27251) since 22 hours ago | 16:30 |
| Brainstorm | New from The Indian Express: World: US to ease foreign travel restrictions, vaccines mandatory → https://is.gd/lNqFZQ | 16:36 |
| Brainstorm | New from COVID tweets: Prof. Shane Crotty (@profshanecrotty): 🔵 Filed with the FDAIt looks like they are filing this with the FDA ASAP, with the hope of having FDA EUA authorization before the end of October. The antibody data are clear evidence the vaccine will work in the kids, → https://is.gd/GtJw4i | 16:58 |
| Brainstorm | New from Contagion Live: Adolescent Vaccination Rates Held Steady in 2020, But Pandemic Could Change That: The data, which reflects pre-pandemic vaccination levels, showed human papillomavirus vaccine rates increased among teens ages 13-17. → https://is.gd/pgnFut | 17:09 |
| Brainstorm | New from EMA: What's new: Event: EMA regular press briefing on COVID-19, Online, from 23/09/2021 to 23/09/2021 → https://is.gd/Z6OPrb | 17:19 |
| Brainstorm | Updates for Chile: +277 cases (now 1.6 million), +8 deaths (now 37367), +60267 tests (now 21.3 million) since 23 hours ago | 17:32 |
| Brainstorm | New from Reddit (test): nCoV: An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2 → https://is.gd/rl6AeW | 17:41 |
| Brainstorm | New from The Indian Express: World: UNGA session to see discussions on climate change, pandemic: All you need to know → https://is.gd/ZiwiZB | 18:03 |
| Brainstorm | Updates for United Kingdom: +3709 cases (now 7.4 million), +2905881 tests (now 292.8 million) since 10 hours ago | 18:09 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): I'm so glad to see that Pfizer has data to submit for their vaccine for 5-11 year olds. But any strong assertions about safety, such as for low incidence side-effects like myocarditis, cannot made from a trial of ~1500 children. → https://is.gd/prWwgh | 18:24 |
| Brainstorm | Updates for Greece: +2124 cases (now 632908), +39 deaths (now 14505), +233944 tests (now 18.0 million) since 23 hours ago | 18:34 |
| Elon_Satoshi | Where can I find names of statistical fallacies that are being used for covid-19 misinformation? | 18:49 |
| LjL | i don't know of a document specifically covering them in relation with COVID-19 but you may have more luck searching for statistical "biases" than statistical "fallacies" (although these are not quite the same thing) | 18:54 |
| Elon_Satoshi | Ah | 18:55 |
| Brainstorm | New from WebMD: Alabama’s Deaths Outpace Births for First Time in History: For the first time in Alabama’s known history, the state’s deaths have outpaced its births -- a bleak consequence of the COVID-19 pandemic. → https://is.gd/SZ1YoJ | 18:56 |
| Elon_Satoshi | Someone tried to tell me the survival rates for people with and without the vaccine are 99%. Of course, this may be tecnhnically true, but that doesn't say anything about the decimals, or how many times the death rates are for people with the vaccine vs without. | 18:57 |
| Elon_Satoshi | It's like saying a drop of water and a bucket of water are the same size because if you pour them into the ocean, the ocean remains the same | 18:57 |
| Elon_Satoshi | I wish I could explain that to them, but... I guess people will believe what they want to believe. | 18:58 |
| Brainstorm | Updates for Greenland: +5 cases (now 469), +404 tests (now 68754) since a day ago | 18:59 |
| IndoAnon | Elon_Satoshi: Well, isn't the official website enough? Try looking at israel's data | 19:02 |
| Elon_Satoshi | Official website? | 19:03 |
| IndoAnon | Government's website | 19:04 |
| IndoAnon | There's tons of data | 19:05 |
| IndoAnon | Or check their github | 19:05 |
| IndoAnon | hmm, i wonder where nixonix go | 19:06 |
| Brainstorm | New from WebMD: I Got a ‘Mild’ Breakthrough Case. Here’s What I Wish I’d Known.: I was miserable for five days, am fully recovered a month later and have learned even more about what we do and don’t know about covid now. → https://is.gd/3cVCtl | 19:49 |
| Brainstorm | Updates for Spain: +5988 cases (now 4.9 million), +118 deaths (now 85901), +692151 tests (now 63.7 million) since a day ago | 20:38 |
| Brainstorm | New from StatNews: Covid-19 set to overtake 1918 Spanish flu as deadliest disease in American history: The Covid-19 pandemic is set to become the deadliest disease event in American history, its death toll on the cusp of surpassing that of the 1918 Spanish flu. → https://is.gd/s2QfVm | 21:04 |
| lastshell | bare in mind US population was way less in that time period | 21:07 |
| aradesh | lol. someone was sharing an article saying how about 30,300 peolpe had died within 21 days of a vaccine in england between jan and june this year | 21:42 |
| aradesh | so i found the data i could about 5 year average of deaths from 2015-2019 and computed what you'd expect on average given random 21 day periods and the number of vaccines given out | 21:43 |
| aradesh | and i got 30,200 | 21:43 |
| aradesh | so close! | 21:43 |
| aradesh | interestingly in that period there had been about 55,000,000 doses given out | 21:44 |
| aradesh | whilst england population is also 55 million | 21:45 |
| aradesh | so just had to compute average deatsh in 21 days in that period | 21:45 |
| Brainstorm | New from r/WorldNews: worldnews: A 20-year-old clerk was shot in the face and killed after asking a customer to wear a face mask in Germany. The suspected shooter said he was stressed out by coronavirus measures. → https://is.gd/eWlUrH | 21:47 |
| nixonix | .title https://twitter.com/R_H_Ebright/status/1439968343780249603 r is related and HAL is human airway epithelial (cells). ebright is a legit biosecurity expert, but i have no idea if he thinks those claimed leaked docs are legit | 21:48 |
| Brainstorm | nixonix: From twitter.com: Richard H. Ebright (@R_H_Ebright): ""We will analyze all SARSr-CoV S gene sequences for..proteolytic cleavage sites in S2 and for the presence of potential Furin cleavage sites..[W]e will introduce [...] | 21:48 |
| Brainstorm | New from ScienceNews: Pfizer says its COVID-19 vaccine is safe and works well for kids ages 5–11: A lower dose of the vaccine produced as many antibodies in elementary school–age kids as a full-dose shot did in teens and young adults. → https://is.gd/hUKUjv | 21:57 |
| Brainstorm | Updates for Zambia: +33 cases (now 208502), +1 deaths (now 3639), +9623 tests (now 2.4 million) since a day ago | 22:05 |
| nixonix | .title https://twitter.com/ClaasPotthoff/status/1439885745892823041 see GC b-cell affinity maturation in action, when you dont stop it with too quick second dose (possible explanation) And also could perhaps be prevented with certain adjuvants, that induce cytokine production that attracts Tfh, in follicular dendritic cells | 22:07 |
| Brainstorm | nixonix, the URL could not be loaded | 22:07 |
| nixonix | .title https://twitter.com/ClaasPotthoff/status/1439885745892823041 | 22:08 |
| Brainstorm | nixonix: From twitter.com: Claas Potthoff (@ClaasPotthoff): "nejm.org/doi/full/10.1056/NE…" | 42l - nitter | 22:08 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): How to cultivate a new #SARSCoV2 variantpnas.org/content/118/39… @PNASNews by Emanuel Goldman @Rutgers_NJMS pic.twitter.com/IbYl9cTKq9 → https://is.gd/Py4cH2 | 22:08 |
| nixonix | btw, according to some source i forgot, monoclonal ab treatment can stay in immune system around year or so, so the patients own immune cells continue to produce the infused mAb. i dont know what is the mechanism behind that | 22:15 |
| nixonix | that should be considered when thinking about timing of the vaccination after that treatment. it also may have some effect for selection of immune escape variants in case of reinfection | 22:17 |
| nixonix | what did they do 1320? | 22:18 |
| nixonix | 60% vaxed optimal for new variants to emerge, remember that model... although waned vaxes that leak for many are prob even more optimal, i wonder if they accounted (properly) that | 22:26 |
| Brainstorm | New from r/WorldNews: worldnews: Covid set to overtake 1918 Spanish flu as deadliest disease in U.S. history → https://is.gd/cutGJi | 22:30 |
| grys | nixonix: meaning over 60% is required for new variants *not* to emerge? | 22:31 |
| nixonix | no. ljl could you grep my nick and 60% and variant. i mentioned that model some day but couldnt find it, then found it some other day and linked here | 22:34 |
| nixonix | anyways, that ref to that model was because the topol's tweet and quote in it, above | 22:35 |
| LjL | 2021-09-20.log:[22:26:42] <nixonix> 60% vaxed optimal for new variants to emerge, remember that model... although waned vaxes that leak for many are prob even more optimal, i wonder if they accounted (properly) that | 22:35 |
| LjL | previously 2021-08-09.log:[01:14:00] <nixonix> did you guys read that article i used time to find, that mentioned 60% coverage in their model being ideal for new variants emerging? | 22:35 |
| LjL | let's see if i can find the actual article too... | 22:35 |
| nixonix | thanks for your trouble | 22:36 |
| nixonix | ill save it this time | 22:36 |
| LjL | might it have been this? https://twitter.com/EricTopol/status/1440043372249378820 | 22:37 |
| pwr22 | aradesh: nice work of that data 👍️ | 22:37 |
| nixonix | maybe ill find it from logs with that quote you found. i mentioned it aug 4th, but couldnt find that above without AND operator | 22:37 |
| LjL | yeah now i'm just grepping for "http" in nearby lines | 22:38 |
| LjL | not quite an "and" but you can do this http://reisenweber.net/irclogs/libera/__covid-19/search?q=nixonix.*60%25.*variant | 22:39 |
| nixonix | .title https://www.sciencealert.com/freedom-day-from-covid-raises-the-risk-of-a-resistant-covid-strain-emerging found keywords ideal optimal 60% variant emerge | 22:40 |
| Brainstorm | nixonix: From www.sciencealert.com: A Resistant SARS-CoV-2 Variant Could Emerge Any Time. Here's What Raises The Risk | 22:40 |
| Brainstorm | New from r/WorldNews: worldnews: Vatican says to require COVID-19 health pass for residents, visitors → https://is.gd/DoN1ZF | 22:40 |
| LjL | nixonix, hehe yeah i've often thought that i should add specific keywords to links i post but then i never do it | 22:41 |
| nixonix | ah, ok good tip | 22:41 |
| LjL | ah, "60 percent", i wouldn't have found it anyway, i was looking for "60%" in articles | 22:41 |
| nixonix | its often "per cent" in uk and aus, makes me angry | 22:41 |
| aradesh | pwr22: was back of the envelope style but it got almost the same number haha | 22:43 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: A Resistant SARS-CoV-2 Variant Could Emerge Any Time. Here's What Raises The Risk ( https://www.zotero.org/groups/covid_links/items/QXJS5QX7 ) | 22:43 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains ( https://www.zotero.org/groups/covid_links/items/SWHYCV3X ) | 22:43 | |
| LjL | nixonix, in Zotero i can add both the article and the related paper and then "link" them as related things | 22:44 |
| LjL | (which i just did) | 22:44 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): This should not have happened.ft.com/content/dee942…We🇺🇸have the tools in 2020-1 compared with 1918-9 to prevent fatalities, especially with vaccines that have reduced deaths (vs prior waves) by ~90% in many countries throughout the world pic.twitter.com/B2ugfHpfNW → https://is.gd/LHb4Qh | 22:51 |
| nixonix | when things are complex or just laborious to find out, people tend to save energy and just believe somebody they "trust". also people dont like uncertainties, despite that pretty much everything is more or less uncertain | 23:02 |
| Brainstorm | Updates for Rwanda: +35 cases (now 95292), +21085 tests (now 2.7 million) since 21 hours ago — Burkina Faso: +11 cases (now 14052), +382 tests (now 215716) since a day ago | 23:07 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): More on surpassing the US death toll of the 1918 Pandemic bloomberg.com/news/articles/… by @kristenvbrown and @JonathanJLevin w/ my comments pic.twitter.com/Rc6unicoWo → https://is.gd/7c4d4M | 23:12 |
| nixonix | .title https://old.reddit.com/r/COVID19/comments/ps110k/myocarditis_and_pericarditis_following/ | 23:20 |
| Brainstorm | nixonix: From old.reddit.com: Myocarditis and Pericarditis Following Vaccination with COVID-19 mRNA Vaccines in Ontario: December 13, 2020 to August 7, 2021 : COVID19 | 23:20 |
| nixonix | "The highest reporting rate of myocarditis/pericarditis was observed in males aged 18-24 years following second dose. The reporting rate in this group following the Pfizer-BioNTech vaccine as second dose was 37.4 per million doses and was 263.2 per million following the Moderna vaccine as second dose." | 23:20 |
| nixonix | when 95% are mild (and the remaining 5% still treated with not too much trouble, and not confirmed deaths afaik) that would make for non-mild risks around 2/million for pfizer, and 13/1M for moderna. among 18-24 yo males | 23:21 |
| nixonix | and among young males the risk of non-mild 1/500k for pfizer, and 1/76k for moderna | 23:22 |
| nixonix | excluding allergic reactions (also not known deaths to my knowledge). not too shabby. are there even less risky vaccines? | 23:24 |
| nixonix | .title https://ir.gritstonebio.com/news-releases/news-release-details/gritstone-announces-dosing-first-volunteer-trial-evaluating-self | 23:29 |
| Brainstorm | nixonix: From ir.gritstonebio.com: Gritstone Announces Dosing of First Volunteer in Trial Evaluating Self-Amplifying mRNA as a COVID-19 Vaccine Booster and Immunogenicity Enhancer | Gritstone bio | 23:29 |
| rpifan | why mrna again | 23:30 |
| grys | "Self-Amplifying" mRNA | 23:32 |
| nixonix | sa-rna vaccines encode additiola proteins for replicating mrna, so less synthesized mrna is needed. pfizer had a candidate like that, one of the four in humantrials, but they selected another one | 23:40 |
| nixonix | additional | 23:40 |
| grys | sounds a bit scary | 23:41 |
| grys | because if mrna replicates inside the body, then who is going to stop it | 23:41 |
| nixonix | but that vaccine above, i didnt find any research paper trying to use the name (maybe there is a paper out without that name), they also use non-spike epitopes for t-cell response | 23:41 |
| nixonix | no its just inside the cell, to produce more mrna | 23:41 |
| nixonix | from less | 23:42 |
| grys | does it suggest the mrna never leaves the one cell it was injected into | 23:42 |
| nixonix | they probably can control it, how long it continues. like with poly-(A) tail | 23:43 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The number of lost lives from the pandemic greatly underestimates the years of life lost for each person (avg 9-11 yrs) and their quality-adjusted life years, disproportionately worse for Black and Hispanic populationsacpjournals.org/doi/full/10.73… @AnnalsofIM @JulianReif @AnnalsofIM pic.twitter.com/ScTHfPRClW → https://is.gd/QgDIu4 | 23:54 |
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