| nixonix | .title https://twitter.com/KeithMEWAS/status/1437017498596122624 | 00:02 |
|---|---|---|
| Brainstorm | nixonix: From twitter.com: Keith DaBe (@KeithMEWAS): "This is not a joke. The Chinese national hockey team just arrived in Sweden. Seriously afraid of coming to Covid Land. Curious to know how they will dress for match in the [...] | 00:02 |
| nixonix | (swede's cases have been low recently, i heard not testing kids with symptoms though, but crept to EU levels or close now) | 00:04 |
| nixonix | swedes' | 00:04 |
| nixonix | .title https://twitter.com/DrEricDing/status/1436842739891593217 | 00:07 |
| Brainstorm | nixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "2) Bathroom airborne transmission confirmed. Whether breathing, toilet plume, or fecal aerosols doesn’t matter—it stayed in air for 40 minutes before infecting next [...] | 00:07 |
| Brainstorm | New from Medical Xpress: Chinese city with coronavirus outbreak stops buses, trains: A city in southern China that is trying to contain a coronavirus outbreak told the public Sunday not to leave town, suspended bus and train service and closed cinemas, bars and other facilities. → https://is.gd/lR3eSd | 00:09 |
| nixonix | .title https://twitter.com/davenewworld_2/status/1436832674199576580 anti-/no-vaxing opinions were common among midwifes in one british survey that i saw. and brits are among the most pro-ronavax countries | 00:10 |
| Brainstorm | nixonix: From twitter.com: Fifty Shades of Whey (@davenewworld_2): "A hospital in New York is forced to pause baby deliveries after 30 members of their staff quit over the vaccine mandate. 96% of doctors are fully vaccinated [...] | 00:10 |
| nixonix | ...wives. sigh | 00:11 |
| nixonix | i know a case where a midwife almost forced a mother to take aqua vesicle or whatever they are. some flipism like silver water etc | 00:14 |
| nixonix | .title https://jamanetwork.com/journals/jama/fullarticle/2784015 has prob been here, but since persistent interest for those rare adverse effects, in case it wasnt | 00:31 |
| Brainstorm | nixonix: From jamanetwork.com: Surveillance for Adverse Events After COVID-19 mRNA Vaccination | Vaccination | JAMA | JAMA Network | 00:31 |
| lastshell | hi guys/gals, seems like humans don't care anymore deaths and cases are on the rise | 00:36 |
| lastshell | is there any positive news something good ? | 00:38 |
| trbp | lastshell: by definition news are tending to be more negative than positive so to speak | 00:38 |
| lastshell | true | 00:38 |
| trbp | good news is you are still living and if you are vaccinated you should not care the other numbers unless you do not trust your very own vaccination | 00:39 |
| lastshell | I got vaccinated and doing more than 150 minutes exercicse per week | 00:39 |
| lastshell | not super healthy in food choices but trying | 00:40 |
| trbp | i do not understand how that relates to eachother but good for you | 00:40 |
| lastshell | but I fear for some relatives that are older than 60 | 00:40 |
| trbp | lastshell: are they vaccinated? | 00:40 |
| lastshell | yes some AZ some Pfizer | 00:40 |
| Brainstorm | New from Eric Topol: @EricTopol: New definition of “rock of Gibraltar”The place where >99% of its population has been fully vaccinated. → https://is.gd/OoYGxp | 00:40 |
| trbp | lastshell: do you trust in those products? | 00:41 |
| lastshell | I got pzifer | 00:41 |
| trbp | that was not the question | 00:41 |
| lastshell | it seems to do there job but after some months the antibodies go down | 00:41 |
| lastshell | I don't know | 00:41 |
| trbp | so? conclusion? | 00:41 |
| lastshell | I hope it works | 00:42 |
| trbp | either get them revaccinated for some boost | 00:42 |
| lastshell | yeah | 00:42 |
| trbp | or live with the lower antibodies and hope for the best... | 00:42 |
| lastshell | ty trbp | 00:43 |
| lastshell | we continue to masking | 00:43 |
| trbp | well now we could also make the others responsible for our own probability of getting infection by them | 00:43 |
| trbp | so we could insist on vaccination of them too | 00:43 |
| lastshell | yeah sadly I'm close to the south in US, to many people don't want to get vaccinated | 00:44 |
| trbp | but each vaccination is also a risk and besides shouldn't adults be able to decide themself what is good for them or not? | 00:44 |
| lastshell | yeah, currently is a mix the joe biden mandatory vaccination over here | 00:45 |
| lastshell | some business agree others don't | 00:45 |
| trbp | well it is all about tolerance and oppression | 00:45 |
| trbp | tolerating others standpoint or oppressing own beliefs disbelives into others ;) | 00:45 |
| lastshell | also some folks argue about natural inmunity | 00:46 |
| lastshell | thanks trbp for listening | 00:47 |
| trbp | last i heard/read about here is more like question is not if someone is immune by nature before getting infected or after the infection the immune system achiving that... | 00:54 |
| trbp | but the ones who get infected and the system is such badly coping with the illness that the form of illness could be dangerous for the patient | 00:55 |
| trbp | so optimal would be to get vaccination so that at least the illness will not revert to such worse situation | 00:56 |
| trbp | still all is not written in stone all probablity numbers statistics and nobody can gurantee 100% of 100% things | 00:57 |
| trbp | complications of vaccines should not be as bad as complications if not been vaccinated and so on | 00:58 |
| lastshell | yeah, I recall I didn't want the vaccine but I saw in the knews the "delta" in India (before was called Delta) | 00:59 |
| lastshell | I decided to get vaccinated next day | 00:59 |
| lastshell | I just got arm pain in the 2 shots totally worthed imho | 00:59 |
| trbp | well i got it too, i am pretty sure i had my share of sideeffects that were not soo easy but still i trust that numbers and statistics if taken carefully show a good probability forecast that to be vaccinated is overall better than not | 01:01 |
| lastshell | exactly | 01:01 |
| trbp | still i cannot and will not say or take the decision of each and everybody to be taken themselves if to be or not, as any vaccination can be also a threat to the participant | 01:02 |
| trbp | that is the strangeness of big numbers and statistics | 01:02 |
| trbp | that 1 person in all that billions dieing from something can be neglectable if in no context to you | 01:03 |
| trbp | and other way around you could spare the billions if the one is a beloved one ;) | 01:03 |
| LjL | I see a slightly imbalance here between Sicily and Lombardy when I look at positives vs notifications sent... https://www.immuni.italia.it/dashboard.html not entirely sure why that would be. just denser population in Lombardy? | 01:19 |
| LjL | <Brainstorm> New from r/WorldNews: worldnews: England vaccine passport plans ditched, Sajid Javid says - BBC News → https://is.gd/7myNtf | 01:47 |
| pwr22 | <LjL> "wut, no one has been talking..." <- I was reading earlier / whenever nixonix mentioned me (plus our conversation the otherday) | 01:48 |
| LjL | i see | 01:48 |
| pwr22 | I mean, you'd think it would be easy to at least test the effects of the BP meds | 01:49 |
| pwr22 | Since there's already a large population taking them and not taking them | 01:49 |
| pwr22 | But the details of the angiotensis/renin-adolsterone stuff and it's effect on covid stuff, that's probably much harder to measure and speculate about | 01:50 |
| pwr22 | s/angiotensis/angiotensin/, s/adolsterone/aldosterone/ | 01:50 |
| pwr22 | Honestly I thought I would have had fairly bad symptomatic covid by now but I got vaccinated and take an ARB | 01:52 |
| pwr22 | So my personal theory is something is protecting me lol, but I have no good reason to believe that, it's just a hunch | 01:52 |
| pwr22 | So my rational certainty of that is very low | 01:52 |
| pwr22 | But I am certainly interested to know about these things | 01:52 |
| pwr22 | Hell, maybe we'll end up learning more about blood pressure regulation / human homeostasis in general out of all the badness of the pandemic? | 01:53 |
| Brainstorm | New from r/WorldNews: worldnews: England vaccine passport plans ditched, Sajid Javid says - BBC News → https://is.gd/gGde75 | 01:53 |
| soldier | i have a question | 02:07 |
| soldier | is there any viruses worse the the delta variant? | 02:07 |
| LjL | err, yes? | 02:08 |
| LjL | there are plenty of extremely scary viruses | 02:08 |
| soldier | ok i wonder what kind of covid viruses is the worst | 02:09 |
| LjL | okay *covid* viruses | 02:09 |
| LjL | that's not the same as "viruses" | 02:09 |
| LjL | Delta might be the "worst" in many sense so far, but Mu may be more vaccine-evading | 02:09 |
| soldier | thank you LjL | 02:10 |
| Brainstorm | New from r/WorldNews: worldnews: Singapore reaches 80 pc double-vaccination rate but life is not returning to normal → https://is.gd/mBOcop | 02:25 |
| LjL | :( | 02:40 |
| de-facto | .title http://medrxiv.org/cgi/content/short/2021.09.06.21263149v1 | 02:59 |
| Brainstorm | de-facto: From medrxiv.org: Reduced magnitude and durability of humoral immune responses by COVID-19 mRNA vaccines among older adults | medRxiv | 02:59 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.09.10.21263385v1 | 02:59 |
| Brainstorm | de-facto: From www.medrxiv.org: Effectiveness of the Single-Dose Ad26.COV2.S COVID Vaccine | medRxiv | 02:59 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.09.08.21263095v1 | 03:00 |
| Brainstorm | de-facto: From www.medrxiv.org: Exposures to different SARS-CoV-2 spike variants elicit neutralizing antibody responses with differential specificity towards established and emerging strains | medRxiv | 03:00 |
| Brainstorm | New from Science-Based Medicine: Peer review of a VAERS dumpster dive: A new preprint study on COVID vaccine myocarditis dives into the VAERS dumpster with predictable and embarrassing results. The post first appeared on Science-Based Medicine . → https://is.gd/pUl8UZ | 03:07 |
| Brainstorm | New from r/WorldNews: worldnews: Denmark lifts almost all COVID pandemic restrictions → https://is.gd/y0KKOA | 05:24 |
| Brainstorm | New from The Indian Express: World: North Korea tests first ‘strategic’ cruise missile with possible nuclear capability → https://is.gd/HvgIZ5 | 06:06 |
| Brainstorm | New from r/WorldNews: worldnews: New Zealand’s largest city remains in lockdown → https://is.gd/qnH12d | 07:18 |
| -Bridgestorm- 🏠 Temblor! Sismo! Earthquake! 6.0 M tremor, registered by EMSC,GEOFON,alomax, with 29 reports, 24 early, occurred 9 minutes ago (05:18:10 UTC), with a crescent moon, Chile-Argentina Border Region (-23.93, -67.01) ± 2 km, ↓3 km likely felt 640 km away (in Salta, San Salvador de Jujuy…) by 766500 people (www.seismicportal.eu) | 07:27 | |
| -Bridgestorm- ⭕ Sismo! Earthquake! 6.1 Mww tremor, registered by US, occurred 22 minutes ago (05:18:13 UTC), with a crescent moon, Chile-Argentina Border Region (-23.88, -67.0) ± 1 km, ↓186 km likely felt 290 km away (in Salta, San Salvador de Jujuy…) by 766500 people (earthquake.usgs.gov) | 07:40 | |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | September 13, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/EKSf0o | 09:04 |
| Brainstorm | New from EuroNews: Green bonds: Can the EU really become the world's largest issuer of climate-conscious finance?: The European Commission is about to issue its first-ever green bonds to finance the post-coronavirus recovery. The market is expected to reach $1 trillion by 2023. #BrusselsBureau → https://is.gd/xrcHtF | 10:38 |
| Brainstorm | New from StatNews: A vaccine veteran steps away from the NIH, looking out toward the world: Barney Graham, who recently stepped down from his post at the Vaccine Research Center, spoke with @helenbranswell about why he left and where he's going. → https://is.gd/rTeYqD | 10:48 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Comirnaty, COVID-19 mRNA vaccine (nucleoside-modified), COVID-19 virus infection, Date of authorisation: 21/12/2020, Revision: 11, Status: Authorised → https://is.gd/golaYG | 10:59 |
| Brainstorm | New from The Indian Express: World: Despite COVID risks, many leaders plan to attend UN General Assembly → https://is.gd/TjaNoP | 11:10 |
| Brainstorm | New from BBC Health: Covid: More than 300,000 suspected of breaking quarantine rules: It comes as the prime minister prepares to announce his winter Covid plan, including for booster jabs. → https://is.gd/TJQNyi | 11:41 |
| Brainstorm | New from BMJ: Biliary colic: What you need to knowArrange liver function tests and routine outpatient abdominal ultrasonography for all patients with suspected biliary colicAcute, persistent, right upper quadrant pain, systemic... → https://is.gd/kVly8y | 12:02 |
| Brainstorm | New from BMJ: Covid-19: US imposes mandatory vaccination on two thirds of workforce: All US companies employing more than 100 people must require their staff to be fully vaccinated or have weekly covid tests, said President Joe Biden in a televised speech that was marked by a new,... → https://is.gd/xoS9w2 | 12:13 |
| specing | why is everyone so afraid of mandatory vaccination? | 12:16 |
| specing | the governments, I mean | 12:16 |
| Brainstorm | New from Reddit (test): CoronavirusEU: Effectiveness Over Time & Delta | “Based on these studies [...] it can be said that the vaccines still work very well and provide excellent protection.” → https://is.gd/CNDGhS | 12:45 |
| Brainstorm | New from r/WorldNews: worldnews: More than 300,000 suspected of breaking quarantine rules → https://is.gd/ix8BMm | 13:16 |
| lastshell | https://www.npr.org/sections/goatsandsoda/2021/09/12/1035571714/why-the-world-should-be-more-than-a-bit-worried-about-indias-nipah-virus-outbrea | 13:21 |
| Brainstorm | New from The Indian Express: World: New Zealand keeps Auckland in strict lockdown to beat Delta → https://is.gd/PTJewB | 13:58 |
| Brainstorm | New from Science-Based Medicine: Dumpster diving in the VAERS database to find more COVID-19 vaccine-associated myocarditis in children than the CDC: "Dumpster diving" is a term used to describe studies using data from the Vaccine Adverse Events Reporting System database by authors, almost always antivaxxers, who don't understand its limitations. Last [... want %more?] → https://is.gd/D5hqzh | 14:09 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Utahns’ choices are ‘hurting children,’ doctor warns, as more kids get sick with COVID-19 → https://is.gd/IbINyw | 14:31 |
| de-facto | .title https://www.biorxiv.org/content/10.1101/2021.08.23.457229v1.full | 14:40 |
| Brainstorm | de-facto: From www.biorxiv.org: mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern | bioRxiv | 14:40 |
| Brainstorm | New from Reddit (test): nCoV: COVID19-UNITED AS ONE original song → https://is.gd/51SU3f | 14:42 |
| Brainstorm | New from StatNews: FDA vaccine regulators argue against Covid-19 vaccine boosters in new international review: A group of international experts — including, notably, two outgoing FDA vaccine regulators — argues in a new paper against offering Covid-19 vaccine boosters to the general population. → https://is.gd/hUcddU | 15:13 |
| Brainstorm | New from Eric Topol: @EricTopol: Analysis of all covid deaths in England from Jan-July 2021 (total 51,281) shows 0.8% were in fully vaccinated breakthrough cases: median age 84, 13% immunocompromisedIn contrast, 37.4% were among unvaccinatedhttps://www.ft.com/content/03c21dd0-f5cc-45f6-a10f-44ddd63a75af by @valentinaromei @FT → https://is.gd/rGPtOD | 15:24 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: International experts argue against Covid-19 boosters; centrist House Dems to release separate drug-pricing proposal → https://is.gd/nHI4ii | 15:35 |
| specing | Lol, still against boosters as if that will magically make vaccines more available for the undeveloped world | 15:54 |
| specing | as if that world can afford $40 / person mrna shots | 15:55 |
| specing | They'll be getting AZ shots, which is also not a problem here because noone wants to take those anyway | 15:55 |
| specing | (and actually, they'll probably be getting the chinese vaccines) | 15:56 |
| pwr22 | And AZ seems to last longer | 15:56 |
| pwr22 | iirc? | 15:56 |
| LjL | possibly | 15:57 |
| LjL | that study was an extrapolation, we haven't *seen* it last longer yet | 15:57 |
| specing | I don't know, but here it was given with 8 week spacing, which might make it look like that | 15:57 |
| Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: With the data, there wouldn't be any guessing games about whether boosters are needed for the J&J vaccine. We would know that alreadyhttps://www.nytimes.com/2021/09/13/briefing/johnson-and-johnson-boosters-explainer.html?searchResultPosition=2 by @DLeonhardt → https://is.gd/ifpah9 | 15:57 |
| specing | AZ is basically J&J + booster, no? | 15:57 |
| pwr22 | Ah, I didn't realise | 15:57 |
| LjL | pwr22, basically they saw the curve at which Pfizer antibodies went down was steeper than the one for AZ. but they didn't witness them *meet* yet | 15:57 |
| Brainstorm | New from BBC Health: (news): Covid: Single jab recommended for 12-15 year olds by UK's top doctors → https://is.gd/bmluHq | 16:07 |
| Brainstorm | New from WHO Euro: Lessons learned from the COVID-19 pandemic – achieving resilience for the next health emergency: A new strategic document was officially presented at the “Lessons learned from COVID-19: getting ready for the next pandemic” event, on 13 September – part of the 71st session of the WHO Regional Committee for Europe (RC71). [... want %more?] → https://is.gd/JJUute | 16:18 |
| Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: Here's the @ONS report on deaths by vaccination status → https://is.gd/bvoii0 | 16:29 |
| Brainstorm | New from Politico: Coronavirus: Top UK doctors green-light coronavirus jabs for kids aged 12 and over → https://is.gd/GzCApi | 16:50 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: 'Hybrid immunity': Why people who had Covid should still get vaccinated https://www.nbcnews.com/health/health-news/hybrid-immunity-people-covid-still-get-vaccinated-rcna1974 → https://is.gd/YMQo9y | 17:01 |
| Brainstorm | New from ProPublica: Survivors and Families of Victims of a 1981 El Salvador Massacre See Justice Slip Away Again: by Raymond Bonner and Nelson Rauda for ProPublica ] ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. In a makeshift courtroom on the second floor [... want %more?] → https://is.gd/MMKuLc | 17:12 |
| Brainstorm | New from Reddit (test): Monday 13 September 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://is.gd/K3g3A1 | 17:23 |
| Brainstorm | New from Eric Topol: @EricTopol: A French nursing home outbreak involving 14 fully vaccinated residents with the Alpha (B.1.1.7) variant https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783985 @JAMANetworkOpen → https://is.gd/SeyDc5 | 17:34 |
| pwr22 | <Brainstorm> "New from ProPublica: Survivors..." <- LjL: looks like this slipped through the covid feeds by accident? | 17:36 |
| LjL | %more | 17:38 |
| Brainstorm | LjL, [...] of a nondescript brick building in northeastern El Salvador, Judge Jorge Guzmán has spent the last six years painstakingly gathering evidence from the survivors of one of the worst massacres in the modern history of Latin America: the slaughter of a thousand old men, women and children by the Salvadoran army during the country’s civil war. Forty years [...] → https://paste.ee/p/SvtPA | 17:38 |
| LjL | pwr22, hmm for some silly reason it appears that ProPublica publishes the *whole* article inside what's normally the title / short description, so there's bound to be a term somewhere in there that triggers it | 17:38 |
| pwr22 | Ah right | 17:40 |
| LjL | i might have to remove it if it's always like this http://feeds.propublica.org/propublica/main | 17:40 |
| pwr22 | Maybe you could truncate the text you search to less characters maybe? | 17:40 |
| pwr22 | Oh wow that's horrific | 17:41 |
| pwr22 | It's got HTML in there | 17:41 |
| pwr22 | I guess just use the title for prorepublica? | 17:42 |
| Brainstorm | New from BMJ: Covid-19: Children aged 12-15 should be offered vaccine, say UK’s chief medical officers: All children aged 12 to 15 should be offered covid-19 vaccination, the UK’s chief medical officers (CMOs) have said.Setting out their advice to the government, the UK’s four CMOs said they had made... → https://is.gd/FB2AUp | 18:17 |
| Brainstorm | New from The Indian Express: World: Africa: COVID lockdowns blamed for increase in teenage pregnancies → https://is.gd/ks0HO8 | 19:11 |
| Brainstorm | New from NPR: A Man Died After Being Turned Away From 43 ICUs At Capacity Due To COVID, Family Says: Ray DeMonia didn't die from COVID-19, but after the 73-year-old experienced a cardiac emergency, he was turned away from dozens of packed ICUs, his family says. → https://is.gd/gG94Qb | 19:23 |
| specing | 43 ICUs?!?!?! | 19:25 |
| darsie | I guess a car was involved. | 19:32 |
| darsie | Or a phone. | 19:32 |
| Brainstorm | New from Contagion Live: mRNA Vaccines Against SARS-CoV-2 Differ in Antibody Response: Pfizer-BioNTech and Moderna mRNA vaccines provoke different levels of antibody response within and between age groups. → https://is.gd/z4oYSa | 20:06 |
| lastshell | be open minded with this video https://odysee.com/@DarkHorsePodcastClips:b/Early-treatment-for-COVID:0 | 20:09 |
| lastshell | they talk about early treatment | 20:10 |
| pwr22 | Saw Joe Rogan and clicked away | 20:12 |
| LjL | pwr22, i'm not going to make such a specific exception in the code, if it keeps being bothersome i'll just remove propublica :P | 20:15 |
| LjL | can't/won't cater for every quirk of individual websites | 20:15 |
| LjL | i've already begrudgingly added ad-hoc twitter support for %title | 20:15 |
| lastshell | Joe Horse Rogan | 20:26 |
| Brainstorm | New from Derek Lowe: @Dereklowe: This has been a clear trend: everything except a vaccine. Anything at all except a vaccine. Stuff from the cleaning cabinet, from the farm supply store, from the auto parts place, just to avoid the vaccine. → https://is.gd/HSydvX | 20:38 |
| specing | idiot government could just import the chinese vaccine and shut down this argument | 20:39 |
| specing | in one simple step | 20:39 |
| de-facto | i wish they would measure nAB titers more frequently so see if the curve is staight or got a kink on log plot as function of time | 20:56 |
| de-facto | if its straight its an exponential decay, but if it got a kink at some point it may hint that more contribution of antibody production now comes from a slower decaying cell line such as memory B-cells or such | 20:57 |
| de-facto | i mention that because possibly it could matter when comparing immunity decay rates at which phase it is | 20:58 |
| de-facto | e.g. comparing AZ with BNT or mRNA | 20:58 |
| nixonix | anyone knows where to check cytokine profiles of these current approved ronavaxes? those starting with CXCL or IL- something (or TNF, INF etc) | 21:00 |
| nixonix | yeah, there are different componets affecting, other than circulating abs too. you saw that mouse study by iwasaki? | 21:01 |
| nixonix | i found something for az, but not nearly all, in some recent study, despite "immunogenicity" in name | 21:06 |
| specing | de-facto: ? BNT is mRNA or something else? | 21:07 |
| specing | I mean, BNT= BionTech? | 21:07 |
| nixonix | what was that study that showed AZ had a strong cd8 response? | 21:12 |
| de-facto | yeah i meant BioNTech and modeRNA | 21:13 |
| de-facto | nixonix, what about the original paper of U Sahin? https://www.medrxiv.org/content/10.1101/2020.12.09.20245175v1.full-text | 21:15 |
| nixonix | ty. doesnt help enough, only a few listed | 21:17 |
| nixonix | but i found some more for az. not the one reporting killer t-cells yet, though | 21:17 |
| nixonix | it seems CXCL13 is needed both for cd8 cells and follicular t-cells. and it depends on il-17, so either one would be needed to find out if it supports good b-cell maturation in germinal centers | 21:19 |
| nixonix | in that az paper around half had il-17, but not nearly all | 21:19 |
| nixonix | CpG adjuvant should produce cxcl13 | 21:20 |
| Brainstorm | New from The Atlantic: Are Pandemic Hospitalization Numbers Misleading Us?: At least 12,000 Americans have already died from COVID-19 this month, as the country inches through its latest surge in cases. But another worrying statistic is often cited to depict the dangers of this moment: The number of patients hospitalized with COVID-19 in the United [... want %more?] → https://is.gd/vrfdWp | 21:21 |
| nixonix | or more like cxcl13 would be needed, then il-17 would be produced by helper t-cells (not sure if cd8 too) | 21:23 |
| nixonix | apparently follicular dentritic cells express cxcl13 causing migration of b-cells to germinal centeres, which might be lacking with these mrna vaccines | 21:29 |
| nixonix | not sure of its role in cd8 killer t-cells, but they have the same receptor cxcr5, so maybe good killer t-cell response tells about its presence | 21:32 |
| nixonix | well, this hints that i might have found the culprit. pfizer: "Plasma CXCL13, which has been reported as a plasma biomarker of early germinal center activity (51), also did not change following vaccination in either cohort" | 21:34 |
| nixonix | .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885942/ | 21:34 |
| Brainstorm | nixonix: From www.ncbi.nlm.nih.gov: Robust immune responses after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2 experienced individuals | 21:34 |
| nixonix | severe rona is good for memory b-cells: "elevated plasma CXCL13 levels at later time points post-symptom onset have been associated with severe COVID-19" | 21:36 |
| nixonix | there might be other factors too, but robust cxcl13 expression (or if not studied, maybe checking il-17 is enough) may be essential for lasting protection for severe symptoms | 21:38 |
| nixonix | and it looks like in az around half of vaccinees were found cxcl13, which is not great | 21:39 |
| nixonix | maybe the levels for those that have it, were not that big then | 21:40 |
| nixonix | are you guys doubting my EazyScience methods? | 21:41 |
| nixonix | good | 21:43 |
| nixonix | next we should find out the adjuvants and combinations promoting robust cxcl13. i found some list, but its short for some adjuvants, like AS03, and missing saponin | 21:46 |
| nixonix | that oral vax had some bacterial adjuvant. another bacterial adjuvant induced cxcl13, so it might work | 21:48 |
| Brainstorm | New from Eric Topol: @EricTopol: Analysis of over 2 million #SARSCoV2 genomes to determine which mutations drive contagiousness "Highlighting the key role of non-S (spike protein) mutations, particularly in N, ORF1b, and ORF1a, in promoting increased growth rate." https://www.medrxiv.org/content/10.1101/2021.09.07.21263228v1 → https://is.gd/Tw9Ehs | 21:52 |
| nixonix | anything new and interesting in that new neutralization study? | 21:55 |
| nixonix | "tiered restrictions might require a careful review as they did not seem to have exercised a mitigating influence on the epidemic when they were first introduced nationwide on November 6 th 2020 | 22:00 |
| nixonix | italy | 22:00 |
| nixonix | "putative transmission-promoting substitutions in N at positions 160-210 is remarkable, but is supported by a similar observation in Ebola .. in that region increase the efficiency of viral packaging | 22:03 |
| nixonix | also listed several possible transmission enhancing mutations in ORF1. not all about S | 22:07 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.07.21263228v1?rss=1 | 22:07 |
| Brainstorm | nixonix: From www.medrxiv.org: Analysis of 2.1 million SARS-CoV-2 genomes identifies mutations associated with transmissibility | medRxiv | 22:07 |
| Brainstorm | New from BBC Health: (news): Covid jab rollout for 12 to 15-year-olds to start in schools in England → https://is.gd/LKLVcb | 22:14 |
| nixonix | .title https://www.nature.com/articles/s41422-021-00519-4 | 22:17 |
| Brainstorm | nixonix: From www.nature.com: SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target | Cell Research | 22:17 |
| nixonix | E alone seems pathogenic. cell death, inflammation, macrophage infiltration. understanding mechanics requires more knowledge on viral and cell membrane ion channels than i have | 22:18 |
| nixonix | slovakia started to vax 5+ yo with pfizer. not all yet, needing pediatric or some expert recommendation | 22:20 |
| nixonix | also according to irene tosetti, risk groups 5+ have been vaccinated already in france, austria, germany, israel | 22:21 |
| LjL | is she upset because italy isn't doing it? | 22:27 |
| nixonix | i dont remember seeing her criticize italy. several other countries, like swithowdoyospellthatmonster often | 22:29 |
| LjL | oh, she lives in switzerland | 22:30 |
| nixonix | she has good information on whats going on, worth following. lots of commenting of other tweets in between, so requires some time | 22:30 |
| nixonix | yeah | 22:30 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.08.21263095v1 variant cross-neutralizing study. too bad it lacked some interesting combinations | 22:44 |
| Brainstorm | nixonix: From www.medrxiv.org: Exposures to different SARS-CoV-2 spike variants elicit neutralizing antibody responses with differential specificity towards established and emerging strains | medRxiv | 22:44 |
| nixonix | see the table on the bottom | 22:44 |
| Brainstorm | New from CIDRAP: COVID cases drop a bit in US as country torn over vaccines, masks: Stephanie Soucheray | News Reporter | CIDRAP News Sep 13, 2021 Americans are evenly split on requiring proof of vaccination for everyday activities. → https://is.gd/Yn4xPe | 22:46 |
| nixonix | .title https://twitter.com/drjohnm/status/1436817772550529033 | 22:48 |
| Brainstorm | nixonix: From twitter.com: John Mandrola, MD (@drjohnm): "Sometimes I do Twitter like I did criteriums: I get excited and make mistakes. Here were two big ones. I regret them but want to own them." | nitter | 22:48 |
| Brainstorm | New from Trevor Bedford: @trvrb: R to @trvrb: Most of this rapid pace of evolution is likely due to adaptation to a new host, but in general, this suggests to me that the S1 domain of spike in SARS-CoV-2 is a readily evolvable domain. 10/12 → https://is.gd/VjmJ10 | 22:57 |
| nixonix | oh, i wrote "cxcl13 causing migration of b-cells to germinal centeres" above. meant follicular t-cells (which migrate to GC, selecting there those B-cells that return to dark zone to continue mutating for enhanced binding) | 23:05 |
| nixonix | readily evolvable. theres some scary scenarios from other ronaviruses like feline | 23:09 |
| nixonix | .title https://en.wikipedia.org/wiki/Feline_infectious_peritonitis | 23:09 |
| Brainstorm | nixonix: From en.wikipedia.org: Feline infectious peritonitis - Wikipedia | 23:09 |
| nixonix | .title https://twitter.com/jbloom_lab/status/1436522202870943749 | 23:12 |
| Brainstorm | nixonix: From twitter.com: Bloom Lab (@jbloom_lab): "Hi @angie_rasmussen, thanks for asking these important questions about risk / benefits of different types of virology experiments. Because you locked your Tweet thread, I [...] | 23:12 |
| nixonix | .title https://twitter.com/ahandvanish/status/1430240967307710469 | 23:14 |
| Brainstorm | nixonix: From twitter.com: Hannah Davis 🌈 (@ahandvanish): "The same group that found hypometabolism in the brains of adult #LongCOVID patients has now found the same in child Long COVID patients 😣 [...] | 23:14 |
| nixonix | not saying crossing blood-brain barrier is common, but could that happen with virion capture through endothelium, with aid of IgA (it can, but i dont know if that leads to crossing BBB) | 23:18 |
| de-facto | interesting how simiar the treatment for FIP is in many aspects, Remdesivir, Prednisolone | 23:19 |
| de-facto | yet vaccination in cats against FIPV spikes does not seem to work | 23:21 |
| de-facto | so its a bit different then | 23:21 |
| nixonix | ill find you some twitter speculation a bit later | 23:22 |
| nixonix | if you really want to open these doors, that you may not get closed then... | 23:23 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.09.07.21263228v1 | 23:26 |
| Brainstorm | de-facto: From www.medrxiv.org: Analysis of 2.1 million SARS-CoV-2 genomes identifies mutations associated with transmissibility | medRxiv | 23:26 |
| de-facto | "Repeated emergence of SARS-CoV-2 variants with increased transmissibility necessitates rapid detection and characterization of new lineages. To address this need, we developed PyR0, a hierarchical Bayesian multinomial logistic regression model that infers relative transmissibility of all viral lineages across geographic regions, detects lineages increasing in prevalence, and identifies mutations relevant to transmissibility." | 23:27 |
| de-facto | .title https://github.com/broadinstitute/pyro-cov | 23:29 |
| Brainstorm | de-facto: From github.com: GitHub - broadinstitute/pyro-cov: Pyro models of SARS-CoV-2 variants | 23:29 |
| de-facto | LjL, something for bookmark? ^^ | 23:32 |
| de-facto | really interesting, linking transmissibility and fitness to parts of SARS-CoV-2 genome | 23:36 |
| nixonix | .title https://twitter.com/EricTopol/status/1437529317014048768 | 23:45 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "What proportion of Americans have some Covid-19 immunity (natural infection or vaccine-induced) as of July 15, 2021? 62%, with marked variability by age groups [...] | 23:45 |
| nixonix | "the overall population immunity was determined as the sum of protection levels in vaccinated persons and those who were previously infected but not vaccinated" | 23:45 |
| nixonix | so they dont wane now? | 23:45 |
| de-facto | sum as if there is no overlap? | 23:47 |
| LjL | de-facto, "6. Work with GISAID to get a data agreement." lol, they have some humor :P | 23:52 |
| LjL | but anyway yeah it looks interesting and kinda like what i wish we'll see one day turn into "variant prediction"... | 23:54 |
| LjL | one limitation i can guess is if it tries to "isolate" advantageous mutations, it might not be able to infer mutations that are advantageous only when they don't come alone | 23:54 |
| de-facto | .title https://imgur.com/a/hwzkwMg https://i.imgur.com/oSZUlwy.png src: https://www.medrxiv.org/content/10.1101/2021.09.07.21263228v1 | 23:58 |
| nixonix | .title https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1016276/Weekly_Flu_and_COVID-19_report_w36.pdf | 23:58 |
| Brainstorm | nixonix: From assets.publishing.service.gov.uk: Weekly Flu and COVID-19 report_w36 (Public Health England) | 23:58 |
| de-facto | "COVID: SARS-CoV-2 growth rate versus date of lineage emergence" | 23:59 |
| nixonix | pdf. check page 79 | 23:59 |
Generated by irclog2html.py 2.17.0 by Marius Gedminas - find it at https://mg.pov.lt/irclog2html/!
